白细胞介素在胃癌发生和发展中的作用

幽门螺杆菌（Helicobacter pylori，H.pylori）感染已被世界卫生组织确定为胃癌危险因素。H.pylori感染引起胃黏膜的炎症，诱导宿主产生多种细胞因子，其中有些因子可导致胃黏膜上皮细胞向癌演变。H.pylori感染后白细胞介素（ILs）表达发生明显改变，不同的ILs在胃癌的发生和发展过程中发挥不同的作用。文章就ILs在胃癌发生和发展中的作用研究进展作一综述。

Roles of interleukins in carcinogenesis and development of gastric cancer

Helicobacter pylori (H. Pylori) infection has been an established risk factor for gastric cancer identified by World Health Organization. H. Pylori triggers chronic inflammation of gastric mucosa and induces host cells to release various cytokines, some of which might lead normal epithelial cells to transfer to gastric cancer. Expression of interleukins in gastric mucosa experiences significant changes after H. Pylori infection. Interleukins play different roles in carcinogenesis and development of gastric cancer. This article briefly reviews the research advances of roles of interleukins in carcinogenesis and development of gastric cancer.