| 霉酚酸粗品结晶母液回收工艺研究 |
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| 引用本文： | 石磊. 霉酚酸粗品结晶母液回收工艺研究[J]. 中国药学杂志, 2011, 46(24): 1948-1951 |
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| 作者姓名： | 石磊 |
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| 作者单位： | 微生物药物国家工程研究中心华北制药集团新药研究开发有限责任公司; |
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| 基金项目： | 国家科技重大专项-重大新药创制(2008ZX09401-005) |
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| 摘 要： | 目的 建立霉酚酸粗品结晶母液有效成分的回收工艺。方法 根据霉酚酸的化学特性,先用NaOH水溶液改变结晶母液pH,使霉酚酸从结晶母液中转化成易溶于水的相应盐,再采用大孔吸附树脂D312作为吸附剂从溶液中提取富集霉酚酸。结果 霉酚酸转化为钠盐收率在90%以上。回收工艺使提取总收率提高了10%以上,产品质量符合要求。结论 霉酚酸结晶母液回收工艺在提高总收率和降低生产成本上操作可行。该工艺具有工业参考的价值,为企业生产提供了一条新思路。
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| 关 键 词： | 霉酚酸 结晶母液 回收工艺 |
| 收稿时间： | 2011-11-11; |
Study on the Recovery Process of Mycophenolic Acid from Mother Liquor of Crude Crystalline |
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| SHI Lei. Study on the Recovery Process of Mycophenolic Acid from Mother Liquor of Crude Crystalline[J]. Chinese Pharmaceutical Journal, 2011, 46(24): 1948-1951 |
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| Authors: | SHI Lei |
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| Affiliation: | SHI Lei(National Engineering Research Center of Microbial Medicine,New Drug R&D Co.Ltd of North China Pharmaceutical Group Co.Ltd,Shijiazhuang 050015,China) |
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| Abstract: | OBJECTIVE To establish a recovery process for mycophenolic acid from mother liquor of crude crystalline.METHODS First,mycophenolic acid was transformed into the form of water-soluble salt by sodium hydroxide solution.Then mycophenolic acid was separated from the solution by macroporous resin D312.RESULTS The yield of transformation was over 90%.The overall yield of mycophenolic acid was increased by 10%,and product's quality met the standards.CONCLUSION This process has the advantages of high yield and low ... |
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| Keywords: | mycophenolic acid crystal-mother liquor recovery process |
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