控释地诺前列酮阴道栓用于延期妊娠引产的药效学初探

 目的 评价控释地诺前列酮阴道栓用于延期妊娠引产的妊娠结果。方法 选择60例因延期妊娠引产的孕妇，随机分为试验组（控释地诺前列酮组）和对照组（催产素组），主要结果的衡量标准是24 h内阴道分娩率及新生儿出生结果。两组计数资料比较分析采用Ridit检验，计量资料采用χ2检验。同时测定孕妇使用后的阴道栓内残余地诺前列酮的含量，进一步分析引产结果与使用地诺前列酮之间的量效关系。结果 试验组24 h内阴道分娩率显著高于对照组（P<0.05），两组新生儿的出生结果没有显著性差异（P>0.05）。地诺前列酮的释放量与放置时间呈指数关系。结论 延期妊娠引产使用控释地诺前列酮阴道栓能取得更好的引产结果，但延长阴道栓的放置时间并不能明显改善引产结果。

Efficacy Evaluation of Controlled-Release Dinoprostone Vaginal Suppositories for Induction of Prolonged Pregnancy

OBJECTIVE To evaluate the efficacy of controlled-release dinoprostone vaginal suppositories for induction of prolonged pregnancy. METHODS A total of 60 pregnant women were randomly divided into two groups and treated with controlled-release dinoprostone and oxytocin respectively. The primary outcome were vaginal delivery within 24 h and the satety of newborns. Ridit test and χ2 test were used for statistical analysis. Furthermore， the concentrations of dinoprostone in the remainder suppositories were determined after induction， and the relationship between the dosage and the rate of successful induction was analyzed. RESULTS The rate of vaginal delivery within 24 h was significantly different between controlled-release dinoprostone and oxytocin (P<0.05)， but the RESULTS of newborns were not significantly different. There exsisted exponential relationship between the concentration of dinoprostone and the retention time of the suppositories in the vagina. CONCLUSION The controlled-release dinoprostone vaginal suppositories have better therapeutic effect in induction. But prolonging the time of use the medicine can not significantly change the result of induction.