| 姜黄素自微乳化释药系统处方优化及体外评价 |
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| 引用本文： | 刘文利,张良珂,贾运涛,袁佩,汪程远,柳静.姜黄素自微乳化释药系统处方优化及体外评价[J].中国药学杂志,2011,46(22):1730-1733. |
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| 作者姓名： | 刘文利 张良珂 贾运涛 袁佩 汪程远 柳静 |
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| 作者单位： | 重庆医科大学药学院;重庆医科大学生命科学院;重庆医科大学附属儿童医院药剂科;重庆工商大学药物化学与化学生物学研究中心; |
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| 基金项目： | 重庆市卫生局课题资助(2010-2-202); 重庆市渝中区科技计划项目资助(20100203) |
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| 摘 要： | 目的 制备姜黄素自微乳化释药系统（Cur-SMEDDS），并考察其体外释药性能。方法 测定姜黄素在各辅料中的溶解度，绘制伪三元相图筛选自微乳化基质，以粒径和溶解度为指标确定最佳处方，并对Cur-SMEDDS的体外释药性质进行研究。结果 Cur-SMEDDS最佳处方组成为：EO-Cremophor RH40-Transcutol P比例为30∶52.5∶17.5，乳化后微乳的平均粒径为36.14 nm。结论 成功制备了Cur-SMEDDS，可显著改善姜黄素的溶解度，有望提高姜黄素的口服生物利用度。
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| 关 键 词： | 姜黄素 自微乳化释药系统 伪三元相图 |
| 收稿时间： | 2011-11-11; |
Formulation Optimization of Curcumin Self-Microemulsifying Drug Delivery System and Its in Vitro Evaluation |
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| LIU Wen-lia,b,ZHANG Liang-kea,JIA Yun-tao,YUAN Peib,WANG Cheng-yuan,LIU Jinga.Formulation Optimization of Curcumin Self-Microemulsifying Drug Delivery System and Its in Vitro Evaluation[J].Chinese Pharmaceutical Journal,2011,46(22):1730-1733. |
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| Authors: | LIU Wen-lia b ZHANG Liang-kea JIA Yun-tao YUAN Peib WANG Cheng-yuan LIU Jinga |
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| Institution: | LIU Wen-li1a,1b,ZHANG Liang-ke1a,JIA Yun-tao2,YUAN Pei1b,WANG Cheng-yuan3,LIU Jing1a(1a.School of Pharmacy,1b.Institute of Life Sciences,Chongqing Medical University,Chongqing 400016,China,2.Department of Pharmacy,Children's Hospital of Chongqing Medical University,Chongqing 400010,3.Research Center of Medical Chemistry & Chemical Biology,Chongqing Technology and Business University,Chongqing 400067,China) |
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| Abstract: | OBJECTIVE To prepare the curcumin self-microemulsifying drug delivery system(Cur-SMEDDS) and study its release characteristics in vitro.METHODS The optimalum formulations of Cur-SMEDDS were screened by solubility experiment,and pseudo-ternary phase diagrams,with average particle size and solubility as parameters.The release curves of Cur-SMEDDS in different release mediuma were measured.RESULTS The optimumal formulation of Cur-SMEDDS was composed of Ethyl oleate/Cremophor RH40/Transcutol P with weight ratio... |
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| Keywords: | curcumin self-microemulsifying drug delivery system pseudo-ternary phase diagram |
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