老年代谢综合征患者血清游离脂肪酸水平及其影响因素

目的 研究老年代谢综合征患者血清游离脂肪酸（FFA）水平及其与其他代谢综合征参数的相关性。方法 在1 372名体检者(≥60岁)中筛选出169例代谢综合征患者（代谢综合征组）及89名体检健康者（正常对照组），测定和比较两组的血压、身高、体质量、腰围、臀围，检测血清生化指标，计算腰臀比、体质量指数(BMI)和胰岛素抵抗指数(HOMA-IR)。结果 代谢综合征组腰围、腰臀比（WHR）、BMI、空腹血糖(FBG)和胰岛素、HOMA-IR及血清三酰甘油(TG)、总胆固醇(TC)和FFA均较正常对照组明显升高，而高密度脂蛋白胆固醇（HDL-C）显著降低（P<0.05）。代谢综合征组血清FFA与WHR、BMI、FBG、HOMA-IR、TG及TC呈显著正相关（P<0.001）；TG和BMI为血清FFA的独立影响因素；当代谢综合征合并糖代谢异常、高脂血症和胰岛素抵抗时，血清FFA明显升高（P<0.05）。结论 血清FFA水平与代谢综合征多种组分相关，其升高可作为代谢综合征的生化标志之一。

Contents of serum free fatty acid in old patients with metabolic syndrome and influencing factors

Objective To investigate contents of serum free fatty acid (FFA) in old patients with metabolic syndrome (MS) and to analyze its correlation with the components of MS. Methods Among 1 372 over 60-year-old people undergoing physical examination, 169 patients with MS and 89 healthy subjects were selected as MS group and control group. The blood pressure, height, weight, waist circumference, and hip circumference were measured. Levels of fasting blood glucose, insulin, blood lipid, and serum FFA were measured. Waist-hip ratio (WHR), body mass index (BMI), and insulin resistance index (HOMA-IR) were calculated. Results The levels of waist circumference, WHR, BMI, fasting blood glucose and insulin, HOMA-IR, blood lipid, and serum FFA in MS group were significantly higher than those in control group. The levels of HDL-C were lower in MS group (P<0.05). Serum FFA level was positively correlated with WHR, BMI, fasting blood glucose, HOMA-IR, triglyceride, and total cholesterol (P<0.001). BMI and triglyceride influenced the level of serum FFA independently. The levels of serum FFA were significantly higher when MS accompanied with glucose disorder, hyperlipemia, and insulin resistance (P<0.05). Conclusion The levels of serum FFA are associated with many components of MS, and high levels of serum FFA is one of biochemical indexes of MS.