| 国产蟾酥药材质量综合评价研究 |
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| 引用本文： | 姬诚,谢媛媛,王义明,陈丽,罗国安.国产蟾酥药材质量综合评价研究[J].中国药学杂志,2011,46(19):1466-1470. |
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| 作者姓名： | 姬诚 谢媛媛 王义明 陈丽 罗国安 |
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| 作者单位： | 清华大学分析中心;江西中医学院; |
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| 基金项目： | 国家科技重大专项课题-重大新药创制专项(2009ZX09308-004) |
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| 摘 要： | 目的 综合考察国产蟾酥药材质量。方法 用HPLC测定14批蟾酥药材中华蟾酥毒基、脂蟾毒配基、蟾毒灵等7种指标成分含量，并考察样品中华蟾酥毒基、脂蟾毒配基、蟾毒灵等7种指标成分TLC鉴别和水分、总灰分、酸不溶灰分、醇浸出物等药材常规理化实验项目。结果 各样品中均可检测出7种指标成分的色谱峰，蟾酥药材指标成分含量和常规理化实验项目测定结果表明，不同产地蟾酥药材间品质差异较大。结论 本实验为蟾酥药材综合质量评价体系的建立提供理论和实验依据。
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| 关 键 词： | 蟾酥 品质评价 华蟾酥毒基 脂蟾毒配基 蟾毒灵 蟾毒它灵 高效液相色谱法 |
| 收稿时间： | 2012-01-01; |
Systematic Quality Evaluation of Venenum Bufonis on Chinese Market |
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| JI Cheng,XIE Yuan-yuan,WANG Yi-ming,CHEN Li,LUO Guo-an.Systematic Quality Evaluation of Venenum Bufonis on Chinese Market[J].Chinese Pharmaceutical Journal,2011,46(19):1466-1470. |
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| Authors: | JI Cheng XIE Yuan-yuan WANG Yi-ming CHEN Li LUO Guo-an |
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| Institution: | JI Cheng1,2,XIE Yuan-yuan1,WANG Yi-ming1,CHEN Li1,LUO Guo-an1(1.Department of Chemistry,Tsinghua University,Beijing 100084,China,2.Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) |
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| Abstract: | OBJECTIVE To systematically evaluate the quality of Venenum Bufonis produced in China.METHODS The contents of 7 marker compounds in 14 samples of Venenum Bufonis were analyzed by HPLC method.The 7 marker compounds in samples was measured by TLC.Some physical and chemical tests(H2O,total ash,acid-insoluble ash and EtOH extract) were done to investigate their qualities.RESULTS The 7 marker compounds were found in 14 samples.There were significant differences in contents of the 7 marker compounds as well as ph... |
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| Keywords: | Venenum Bufonis quality evaluation cinobufagin resibufogenin bufalin bufotalin HPLC |
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