呼出气一氧化氮在儿童哮喘缓解期的应用价值

目的：探讨呼出气一氧化氮检测用于评估临床缓解期哮喘儿童病情的价值。方法选取214例处于临床缓解期哮喘儿童，按照有无进行规范化治疗分为治疗组和对照组。同时记录FeNO及PC20 FEV1数值。结果治疗组与对照组平均FeNO值分别为22．63×10－9 ppb和39．67×10－9 ppb ，差异有统计学意义（ P＜0．01）。治疗组与对照组平均 PC20 FEV1数值分别为（7．43±6．16）和（6．78±5．83），差异无统计学意义（P＞0．05）。FeNO与PC20 FEV1呈负相关性（r＝－0．372，P＜0．01），直线回归方程为Y＝35．883－1．074X（X表示PC20 FEV1，Y 表示FeNO）。结论 FeNO数值可以作为哮喘患儿非特异性气道炎症控制状况的可靠指标。呼出气一氧化氮检测与支气管激发试验联合，可显著提高临床缓解期哮喘患儿的诊断率。

Value of exhaled nitric oxide in remission stage of asthmatic children

Objective To explore the value of exhaled nitric oxide evaluate the condition of children with asthma in clinical remission stage .Methods A total of 214 asthmatic children were divided into treatment group and control group .Tests of bronchial provocation and FeNO were performed at the same time .Results FeNO in treatment group was significantly lower than in control group ,while the level of PC20 FEV1 did not have obvious difference in two groups .The level of PC20 FEV1 was negatively correlated with FeNO ,regression equation was Y=35 .883-1 .074X(X= PC20 FEV1 ,Y= FeNO) .Conclusion FeNO is a reliable indicator to evaluate the control situation of non‐specific inflammation in asthmatic children .Combined with bronchial provocation test ,the diag‐nosis rate of asthma in clinical remission stage will significantly raised .