硫普罗宁治疗化疗药物性肝损伤临床观察 |
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引用本文: | 陈昕,邓红梅,杨健,龚光,袁泉,贾钰铭. 硫普罗宁治疗化疗药物性肝损伤临床观察[J]. 现代医药卫生, 2009, 0(10): 1447-1448 |
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作者姓名: | 陈昕 邓红梅 杨健 龚光 袁泉 贾钰铭 |
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作者单位: | 宜宾市第二人民医院,四川宜宾644000 |
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摘 要: | 目的:观察硫普罗宁治疗化疗药物所致轻度肝损伤的疗效和安全性。方法:将化疗后有轻度肝损伤的60例恶性肿瘤患者随机分为治疗组和对照组各30例,对照组以肌苷0.6g,维生素C 2.0g,维生素B6 0.2g加5%葡萄糖溶液中静脉滴注,每天1次,连续治疗7天;治疗组除上述治疗外。另以硫普罗宁0.2g加5%葡萄糖液中静脉滴注,每天1次,连续治疗7天。同时分别监测肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、总蛋白(TP)、总胆红素(TBi)、总胆汁酸(TBA)等,并进行比较。结果:治疗组较对照组在肝功能复常方面显示良好的治疗效应,使转氨酶明显下降,治疗组与对照组有效率比较差异有显著性(P〈0.01)。结论:短期临床研究资料提示硫普罗宁治疗化疗药物所致轻度肝损伤,可明显改善肝脏功能,不良反应少,疗效显著,保持化疗连续性。
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关 键 词: | 硫普罗宁 化疗 药物性肝损伤 临床观察 |
Effect of tiopronin on liver injury caused by chemotherapy |
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Affiliation: | CHEN Xin,Den Hong-mei,YANG Jian,et al. (Second People 's Hospital of Yibin City, Yibin,Sichuan 644000, China) |
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Abstract: | Objective:To observe the effect of tiopronin on hver injury caused by chemotherapy. Methods:60 cancer patients suffered from slight liver injury after chemotherapy were randomly divided into treatment group and control group,each group 30 patients. The control group was used titamin C ,titamin B6, inosine. The treatment group was used tiopronin in addition to the treatment abovementioned.ALT, AST, TP,TBi and TBA were monitored. Results:The treatment group had significantly better effective ratio to recover the level of ALT compare with control group (P〈0.01).Conclusion:Tiopronin has significantly effect on recovering from hepatic injury after chemotherapy in the patients with cancer. |
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Keywords: | Tiopronin Chemotherapy medicine Hepatic injury |
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