| 前列腺癌VEGF与MMP-2表达和微血管密度的临床病理关系 |
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| 引用本文： | 吴健,张昶.前列腺癌VEGF与MMP-2表达和微血管密度的临床病理关系[J].现代医药卫生,2009(21):3203-3204. |
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| 作者姓名： | 吴健 张昶 |
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| 作者单位： | 南京医科大学附属淮安第一医院病理科,江苏淮安223300 |
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| 摘 要： | 目的：探讨血管内皮细胞生长因子（VEGF）、基质金属蛋白酶-2（MMP-2）和微血管密度（MVD）与前列腺癌的相关性。方法：应用免疫组织化学方法检测48例前列腺癌组织和20例前列腺增生组织VEGF和MMP-2蛋白的表达并计数微血管密度。结果：前列腺癌组织OVEGF、MMP-2的阳性表达率和MVD值显著高于前列腺增生组织（P〈0．01），VEGF、MMP-2的阳性表达率和MVD值与前列腺癌TNM分期和骨转移情况具有相关性（P〈0．05），前列腺癌VEGF、MMP-2的阳性表达率和MVD值呈正相关（P〈O．01）。结论：VEGF、MMP-2的高表达和MVD增高在前列腺癌发生发展中具有重要作用，检测VEGF、MMP-2和MVD对判断前列腺癌的预后具有重要意义。
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| 关 键 词： | 前列腺癌 免疫组化 血管内皮细胞生长因子 基质金属蛋白酶-2 微血管密度 |
Expression of VEGF,NLMP-2 and MVD in prostatic cancer and its relation to clinicopathology |
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| WU Jian,ZHANG Chang.Expression of VEGF,NLMP-2 and MVD in prostatic cancer and its relation to clinicopathology[J].Modern Medicine Health,2009(21):3203-3204. |
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| Authors: | WU Jian ZHANG Chang |
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| Institution: | (Department of Pathology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian,Jiangsu 223300,China) |
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| Abstract: | Objective ：To explore the expression of VEGF, MMP-2 and MVD in prostatic cancer. Methods：Immunohistochemistry was employed to measure the expression of VEGF, MMP-2 and MVD in 48 cases of prostatic cancer and 20 cases of benign prostatic hyperplasia.Results：The positive expressions of VEGF, MMP-2 and MVD between prostatic cancer and benign prostatic hyperplasia were significantly different （P〈0.01）.The positive expressions of VEGF, MMP-2 and MVD were related with the clinical stage and metastasis of prostatic cancer （P〈0.05）.The expression of VEGF, MMP-2 and MVD were positively correlated with prostatic cancer（P〈0.01）. Conclusion：The expressions of VEGF, MMP-2 and MVD are related with the occurrence and progression of prostatic cancer. |
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| Keywords: | Prostatic cancer Immunohistochemistry VEGF MMP-2 MVD |
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