| 盐酸克林霉素胶囊溶出度测定方法研究 |
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| 引用本文： | 张萍,吴捷.盐酸克林霉素胶囊溶出度测定方法研究[J].现代医药卫生,2009(17):2607-2609. |
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| 作者姓名： | 张萍 吴捷 |
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| 作者单位： | 安徽芜湖市药品检验所,安徽芜湖241000 |
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| 摘 要： | 目的：建立紫外分光光度法测定盐酸克林霉素胶囊溶出度的方法。方法：以0．1mol／L的盐酸作为溶出介质，转速为100r·min-1，紫外分光光度法测定溶出量，检测波长为201nm。结果：在12．1—72．7μg/ml内呈良好的线性关系，r=0．9990，精密度RSD为0．12％（n=6）。结论：本方法简单快速，准确稳定，可用于盐酸克林霉素胶囊溶出度。
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| 关 键 词： | 盐酸克林霉素胶囊 溶出度 紫外分光光度法 |
Study on method to determine dissolution of Clindamycin Hydrocldoride Capsules |
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| Institution: | ZHANG Ping, WU fie (Wuhu Institute for Drug Control, Wuhu ,A nhui 241000, China) |
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| Abstract: | Objective：To establish a determination method of dissolution of Clindamycin Hydrochloride Capsules by UV method. Methods：0.1 mol/L hydrochloric acid was used as dissolution medium and the apparatus was operated at the rate of 100 r min-1.The UV method was used. The detection wavelength was at 201 nm.Results：A good linear relationship was obtained when the detection concentration range was 12.1-72.7 μg/mlg （r= 0.9990）;the RSD was 0.12%（ n=6）.Conclusion：The method is rapid, simple and accurate,which can be used for determining the dissolution of Clindamycin Hyduochloride Capsules. |
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| Keywords: | Clindamycin hydroehloride capsules dissolution UV method |
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