嗅神经鞘细胞与雪旺氏细胞在脊髓损伤修复中的作用

雪旺氏细胞和嗅神经鞘细胞都能分泌多种神经营养因子、细胞外基质及黏附因子,提供有利于脊髓神经轴突再生的微环境,且两者都能促进轴突的再髓鞘化和再生。嗅神经鞘细胞具有在中枢神经系统内长距离迁移的能力,能够促进神经轴突穿越移植物一宿主界面重新进入中枢神经系统,其与星型胶质细胞相容性也更好。而雪旺氏细胞在促进轴突髓鞘形成的能力上可能更强。该文就两者在脊髓损伤修复中的作用进行综述,以促进中枢神经再生机制的研究,并为进一步修复脊髓损伤奠定理论基础。

Effects of Schwann Cell and Olfactory Ensheathing Cell for Reparing Spinal Cord Injury

Schwann cells (SC) and olfactory ensheathing cells (OECs) can secrete a variety of neurotrophins, ECM and adhesion molecules to provide a favorable enviroment for the regeneration of spinal cord injury (SCI). Two cells can promote the remyelination and regeneration of the injured spinal axons with a great promise in autotrans-plant. OECs have unique advantages, such as the ability to migrate over long distance, promote axons across the graft-host interface and coexist well with astrocytes. SC could induce more myelinated axons compared with OECs. A com-parision between two cells can boost the mechanism research in CNS regeneration and explore the theoretical basis for reparing SCI.