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Imipramine binding sites on platelets of patients with major depressive disorder
Authors:M E Carstens  A H Engelbrecht  V A Russell  C Aalbers  C A Gagiano  D O Chalton  J J Taljaard
Affiliation:1. Institute for Water and Wastewater Technology, Durban University of Technology, Durban, South Africa;2. Department of Chemistry, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa;3. Department of Chemistry, Umeå University, Sweden;4. Department of Microbiology, University of Uyo, Uyo, Nigeria;1. Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico;2. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona, 18-26, 08034 Barcelona, Spain;3. Catalan Institute of Water Research, Parc Científic i Tecnològic de la Universitat de Girona, c/Emili Grahit, 101, Edifici H2O, 17003 Girona, Spain;4. College of Environmental and Resources Sciences, Zhejiang A&F University, Hangzhou 311300, China;1. Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China;2. School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK;3. Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China;4. Institute of Environmental Resources and Soil Fertilizers, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;5. Department of Agriculture and Biotechnology, Wenzhou Vocational College of Science and Technology, Wenzhou 325006, China;1. Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA;2. Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women''s Hospital, Boston, MA 02115, USA;3. Harvard Medical School, Boston, MA 02115, USA;4. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA;5. Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA;6. Department of Radiology, Massachusetts General Hospital, Boston, MA, USA;7. The German Center for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany;8. Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA;9. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Cambridge, MA, USA
Abstract:3H-Imipramine binding to platelets of patients with primary, unipolar major depressive disorder was investigated and compared to that of a normal, healthy control population. No significant differences could be demonstrated between either the Kd or the Bmax values of the two groups. A negative correlation was observed between imipramine Bmax values and the Hamilton anxiety ratings of the depressed patients. Patients who displayed psychomotor retardation tended to have lower platelet imipramine Bmax values than patients with psychomotor agitation. It is suggested that platelet imipramine Bmax values may be a biological marker for subtypes of depression.
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