药物联合应用在神经外科外伤性癫痫治疗中的临床研究

目的探讨丙戊酸镁联合苯妥英钠治疗外伤性癫痫的临床疗效。方法选择2010年3月至2013年3月外伤性癫痫患者150例，按照治疗方式分为丙戊酸铗治疗组（A组）50例、苯妥英钠治疗组（B组）50例和两药联合治疗组（c组）50例。观察三组患者的治疗效果。结果在控制癫痫发作频率和发作持续时间方面，三组患者治疗后均优于治疗前，差异有统计学意义（P〈O．05）；A组和B组差异无统计学意义（P〉0．05）；C明显优于A组和B组，差异有统计学意义（P〈0．05）。三组总有效率比较，C组明显优于A组和B组，差异有统计学意义（P〈0．05）；A组和B组差异无统计学意义（P〉0．05）。三组不良反应比较差异无统计学意义（P〉0．05）。结论丙戊酸镁联合苯妥英钠治疗外伤性癫痫具有显著的临床疗效，不增加药物的不良反应，患者的耐受性较好，值得临床推广应用。

Clinical study of combined drugs treatment in traumatic epilepsy

Objective To investigate the clinical curative effect of magnesium valprote combined with phenytoin sodium on traumatic epilepsy. Methods One hundred and fifty cases of traumatic epilepsy admitted in our hospital, from March 2010 to March 2013 were selected. They were divided into magnesium valprote treatment group （group A, 50 cases）, phenytoin sodium treatment group （group B, 50 cases） and two drug combined treatment group （group C, 50 cases）, according to the treatment methods. The treat- ment effects of the three groups were observed. Results Seizure frequency and duration of traumatic epi- lepsy attack, were better after treatment than those before treatment in patients of the three groups, there were significant differences （P 〈 0.05） ; There was no significant difference between group A and group B （ P 〉 0.05 ） ; Group C was superior to group A and group B, there were significant differences （ P 〈 0.05 ）. In the overall efficiency rate of the treatment, group C was significantly superior to group A and group B, there were significant differences （ P 〈 0.05 ）, but there was no significant difference between group A and group B （ P 〉 0.05 ）. There was no significant difference among the three groups in the incidence of ad-verse drug reactions （ P 〉 0.05）. Conclusions The treatment of traumatic epilepsy with magnesium val-prote combined with phenytoin sodium has significantly clinical curative effect, with no increase in adverse drug reactions, and patient＇ s tolerance is good, so is worthy to be popularized in clinics.