抗心磷脂抗体与骨创伤后深静脉血栓形成的关系研究

目的探讨骨创伤后深静脉血栓（DVT）的形成与抗心磷脂抗体（ACA）以及C-反应蛋白（CRP）的关系。方法选择创伤骨折患者196例，经彩色多普勒确诊的DVT患者23例。健康查体者116例作为对照组。ELISA法检测抗心磷脂抗体，速率散射比浊法检测C-反应蛋白。结果创伤骨折患者CRP含量显著增高，但低于深静脉血栓患者；深静脉血栓患者ACA阳性率明显增高，5例ACA阳性的骨创伤患者均发生DVT；下肢骨折组、多发骨折组、骨盆骨折组CRP阳性率又高于上肢骨折组（P〈0．05）。结论ACA和CRP与骨创伤后DVT的发生相关，ACA是发生DVT的独立危险因素。

Relationship between anticardiolipin antibodies and deep vein thrombosis after skeletal trauma

Objective To investigate the relationship among anticardiolipin antibodies （ACA）, C-reactive protein （CRP） and deep vein thrombosis after skeletal trauma. Methods One hundred and ninety-six patients with skeletal trauma were chosen for the study, 23 cases of which were definitely diag-nosed by color Doppler. One hundred and sixteen healthy subjects were chose as control group. The level of anticardiolipin antibodies was assayed by enzyme linked immunoabsorbent assay （ELISA） , and CRP was determined by rate nephelometry. Results CRP levels in patients with skeletal trauma were signifi-cantly high, but lower than in patients with deep venous thrombosis ; Positive rate of ACA in patients with deep vein thrombosis was significantly higher, five cases of ACA-positive skeletal trauma patients suf-fered from DVT; Positive rate of CRP in lower extremity fractures, multiple fractures group or pelvic frac-ture group was significantly higher than that in the upper limb fracture group （ P 〈 0.05 ）. Conclusions ACA and CRP may be associated with skeletal trauma; ACA is an independent risk factor for DVT.