老年患者下呼吸道感染铜绿假单胞菌96例临床分析与耐药性调查

目的分析铜绿假单胞菌老年患者下呼吸道感染临床特点,调查铜绿假单胞菌对常用抗生素的耐药情况,为临床控制铜绿假单胞菌所致感染提供参考依据。方法收集96例铜绿假单胞菌老年患者下呼吸道感染的临床资料,分析其感染特点。按照《全国临床检验操作规程》分离鉴定细菌,琼脂纸片扩散（K-B）法进行体外药物敏感试验,观察其耐药情况。结果96例全部患有一种以上基础疾病,其中慢性阻塞性肺疾病加重期（AECOPD）最常见,占75%,96例患者曾先期使用过广谱抗生素,使用过吸氧治疗的占87.5%,曾行介入性导管治疗的占62.5%,血浆清蛋白降低的占72.9%。药敏试验结果表明铜绿假单胞菌对多种抗生素耐药,对复方磺胺、头孢唑林、头孢曲松的耐药率较高,分别为93.7%、83.3%、62.5%,而对哌拉西林/他唑巴坦,亚胺培南和环丙沙星较敏感,敏感率分别为91.4%、85.4%、72.9%。结论铜绿假单胞菌老年患者下呼吸道感染易发生在患有多种基础疾病,免疫功能低下、血浆清蛋白降低和长期使用广谱抗生素及有介入性导管治疗患者。细菌耐药现象严重,临床应尽早进行病原学检查,根据药敏结果选用合适的抗生素。

Clinical analysis of 96 aged patients with lower respiratory tract infection caused by Pseudomonas aeruginosa and investigation on its drug resistance

Objective To analyze the clinical characteristics of lower respiratory tract infection caused by Pseudomonas aeruginosa in aged patients and to investigate the antibiotic resistance for providing the experimental data in clinic.Methods To collect the clinical data of 96 aged patients with lower respiratory tract infection caused by Pseudomonas aeruginosa and to analyze its clinical characteristics.These strains were isolated and determined according to the Operating Rules of Chinese Clinical Laboraory.The a...