异钩藤碱药动学及其含量测定方法研究概述△

目的:归纳异钩藤碱药动学及其含量测定方法的研究进展。方法:查阅国内外有关文献进行综合分析。结果:异钩藤碱是中药钩藤中的主要生物碱之一,目前主要采用HPLC、反相HPLC等方法检测动物组织和血液中异钩藤碱浓度,并进行了异钩藤碱在大鼠、兔、猫体内的药动学研究;采用HPLC、超高效液相色谱、非水毛细管电泳、高效毛细管电泳、薄层色谱傅里叶变换表面增强拉曼散射法测定钩藤药材中异钩藤碱的含量。结论:虽然对异钩藤碱药动学及其含量检测方法研究取得了一定成果,随着科技发展和高端检测仪器的应用,还需采用更加快速、便捷、精确的检测方法,为异钩藤碱今后的进一步研究和开发提供技术支撑。

Research overview of pharmacokinetics of isorhynchophylline and its determination methods

Objective：Isorhynchophylline is one of the major alkaloids of Uncaria rhynchophylla. Methods：To search the related domestic and foreign literatures,and to analyze them comprehensively. Results：In animal tissues and blood,isorhynchophylline concentration is almost measured by high-performance liquid chromatography （HPLC）and reversed-phase HPLC; and its pharmacokinetics is conducted in rat,rabbit, and cat. Isorhynchophylline content in Uncaria rhynchophylla is mainly determined by the methods of HPLC,ultra performance liquid chromatography,non-aqueous capillary electrophoresis,high-performance capillary electrophoresis,and thin layer chromatography-surface enhanced Raman spectroscopy. Conclusions： This paper reviews the above mentioned progress of isorhynchophylline to provide a reference for further research development and utilization.