Retina-derived growth-promoting extract supports axonal regeneration in vivo |
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| Authors: | MJ Politis |
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| Institution: | 1. Center for Molecular Signaling (PZMS), Institute for Molecular Cell Biology, Research Center for Molecular Imaging and Screening, Medical Faculty, Saarland University, Homburg, Germany;2. Department of Physiology, Medical Faculty, Saarland University, Homburg, Germany;3. Cellular Neurophysiology, Hannover Medical School, Hannover, Germany;4. Experimental Physics, Faculty NT, Saarland University, Saarbrücken, Germany |
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| Abstract: | The ability of a growth-promoting extract derived from bovine retina was assessed for its ability to support nerve fiber regeneration from proximal stumps of transected sciatic nerves. Proximal stumps of transected rat peripheral nerves were inserted into the single inlet end of a 6 mm long Y-shaped Silastic implant. One of the paired outlets was attached to an Elvax pellet containing the retina-derived growth extract, and the other outlet to a pellet containing an equivalent amount of tissue extract-free Hank's balanced salt solution. At 3 weeks postoperatively, the number of axons and blood vessels in the midportion of implant forks was assessed. The extent of axonal regeneration and blood vessel formation induced were similar to each other and dose-dependent. Results indicate preferential and dose-dependent growth of axons toward pellets containing the retina-derived growth-promoting extract. |
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| Keywords: | neovascularization axonal guidance |
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