帕金森病静息态脑功能MRI研究

目的：应用血氧水平依赖的功能MRI（BOLD-fMRI），探索帕金森病（PD）患者静息态脑功能可能存在的异常。材料与方法对68例PD患者和36例健康志愿者进行静息态BOLD-fMRI检查。分析PD组与正常对照组标准化脑功能低频振荡幅度（mALFF）的差异。结果与正常对照组比较，PD组在双侧辅助运动区、中后扣带回、楔前叶、海马、海马旁回、外侧苍白球、背侧丘脑、小脑前叶以及右侧局部初级运动皮层、岛叶、尾状核、壳核、小脑后叶等广泛区域mALFF值显著减低（P〈0.05，AlphaSim校正），在双侧前额叶、顶叶及颞叶的广泛外侧皮层、左侧枕叶初级视觉皮层等区域mALFF值显著增高（P〈0.05，AlphaSim校正）。结论 PD患者静息态脑功能存在广泛异常，主要表现为PD患者在运动调节相关脑区、默认网络关键节点、边缘系统等部位神经元活动减弱，在前额叶、顶叶、颞叶的广泛外侧皮层以及初级视觉皮层等部位神经元活动增强。

A resting-state functional MRI study in Parkinson's disease

Objectives：Blood-oxygen-level dependent functional magnetic resonance imaging （BOLD-fMRI） was used to investigate the resting-state brain functional abnormalities in patients with Parkinson＆#39;s disease （PD）. Materials and Methods：Totally 68 clinically diagnosed PD patients with at least 12 hours withdrawal time and age-and gender-matched 36 normal controls （NC） were included to take clinical scale evaluation and resting-state BOLD-fMRI examination. All subjects were scanned with Philips 3.0 Tesla MRI system. The fMRI data were processed and analysed by DPARSF V2.0 soft and REST V1.8 soft. Two-sample t-test was used to examine the mALFF differences between PD group and NC group. Results： Compared to NC group, PD group had significantly decreased mALFF values in extensive brain regions including bilateral SMA, middle and posterior cingulate cortex, precuneus, hippocampus, parahippocampal gyrus, lateral globus pallidus, dorsal thalamus, anterior lobe of cerebellum, and right local primary motor cortex, insular cortex, caudate nucleus, putamen, posterior lobe of cerebellum as well as increased mALFF values in several brain regions including extensive cortex of bilateral anterior frontal, parietal and temporal lobe, and left occipital primary visual cortex （P〈0.05, AlphaSim corrected）. Conclusions：Resting-state brain functional abnormalities of PD patients are extensive. The neuronal activity decreases mainly in several areas including motor regulation related brain regions, default mode network and limbic system, and increases mainly in extensive cortex of anterior frontal, parietal, temporal lobe and primary visual cortex.