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目的了解不同年龄小儿胃酸度变化的特点。方法用便携式pH动态监测仪(Medtronic)对982例不同年龄儿童进行空腹胃pH值测定。结果空腹胃pH值在新生儿期(128例)、~1岁组(288例)、~3岁组(182例)、~7岁组(210例)、~15岁组(174例)分别为2·32±0·90、1·92±0·58、1·66±0·63、1·70±0·48、1·59±0·47。2周不到的新生儿(77例)与大于2周的新生儿(51例)空腹胃pH值分别为2·30±0·92、2·35±0·88,其差异无统计学意义。新生儿组与各组间的差异有统计学意义(P均<0·001);~1岁组与各组间的差异也有统计学意义(P均<0·001)。,而~3岁组、~7岁组和~15岁组之间的差异则无统计学意义(P>0·05)。结论新生儿期胃内已呈酸性环境,但其胃pH值高于婴幼儿及年长儿;随着年龄的增长,胃pH值逐渐降低,1岁以后已接近成人水平;提示酸相关性疾病可发生于包括新生儿在内的儿童。

Gastric acid secretion from neonate to childhood

??AbstractObjectiveTo investigate the gastric acid secretion from neonate to childhood.MethodsIntragastric pH was recorded by ambulatory pH monitoring (Medtronic) in 982 children.ResultsIntragastic pH values were 2.32??0.90??1.92??0.58??1.66??0.63??1.70??0.48??1.59??0.47 in infants for neonates and different groups aged less than 1 year old,3 years old,7 years old,15 years old,respectively.The difference between the neonates and other groups was significant (P<0.001),and was also observed between the group aged less than 1 year old and other groups whereas the difference among groups aged less than 3 years old,7 years old 15 years old had no any significant.The values of gastric pH in neonates less than two weeks and larger than two weeks were 2.61??0.93??2.38??0.92,respectively.No significant difference was observed between these two groups.ConclusionGastric acid secretion were observed in the newborn from the second day of life.The values of gastric pH is significantly higher than that in both infant and older children.Gastric pH values decreases with the development of children,and by 1 year old gastric acid secretion approaches that in adults.Our results suggests that acid??related diseases may occur in all the infants including neonates.