医用生物材料的相关性炎症

目的:概括医用生物材料在宿主体内引起炎症反应的原因和机制.资料来源:以biomaterials,inflammation,mechanism为检索词,检索Pubmed数据库(2004-01/2008-12);以生物材料,炎症,机制为检索词,检索CNKI数据库(2005-01/2008-12).文献检索语种限制为英文和中文.资料选择:纳入产生医用生物材料炎症的原因和机制相关的内容.对医用生物材料的理化特性以及力学方面的研究进行排除.结局评价指标:①材料植入体内后炎症细胞和材料的黏附.②细胞因子的表达.结果:计算机初检得到70篇文献,根据纳入排除标准,对医用生物材料在宿主体内引起炎症反应的原因和机制进行分析.随着组织工程学的发展,各种新型的、具有良好生物相容性、生物活性以及生物降解吸收功能的高分子医学生物材料正不断涌现.生物医学材料是用来修复或替代损伤的组织和器官使其功能恢复的材料,感染仍是医用生物材料植入的严重并发症.生物医学材料导致感染的机制为:血液中的补体黏附生物材料表面,导致整合素介导的白细胞的募集和黏附,黏附的单核,巨噬细胞释放细胞因子和生长因子,导致生物医学材料相关感染的发生.要预防医用生物材料相关性炎症,首先要从材料本身出发,寻找一些对宿主炎症反应小的医用材料.结论:医用生物材料相关性炎症是决定材料植入成功与否的关键因素.生物材料相关炎症的产生是炎症细胞,炎症因子,补体以及酶,氧自由基共同作用的结果.材料表面的微结构、化学和介电等性质都直接影响炎症细胞对材料的反应.

Medical biomaterials-associated inflammation

OBJECTIVE: To summarize the cause and mechanic of inflammation reaction induced by medical biomaterials in the body.DATA SOURCE: A computer-based online search of Pubmed database was undertaken to identify the relevant articles published from January 2004 to December 2008 in English with the key words of "biomaterials, inflammation, mechanism".Meanwhile, with Chinese articles were retrieved from CNKI database between January 2005 and December 2008 with the key words of "biomaterials, inflammation, mechanism".DATA SELECTION: Articles concerning the cause and mechanic of inflammation reaction induced by medical biomaterials were included. Articles addressing physical and chemical features and mechanics of medical biomaterials were excluded.MAIN OUTCOME MEASREUS:①After the material implants in vivo, inflammatory cell and material adhering.②Cell factor expression.RESULTS: After initially examined 70 literatures were obtained. According to inclusion and exclusion criteria, the reasons and the mechanism related to the medical biological material in host in vivo for causing the inflammation were analyzed. Along with the tissue engineering development, various new high-polymer medicine biological materials with good biological compatibility,the biological activity and the biodegradation absorption function are emerging unceasingly. The biomedicine material was used to repair or substitute damage organization and the organ, and to cause function recovery. The infection was still the serious complication following the medical biological material was implanted. The mechanism of biomedicine material-induced infection is: complement in blood adhere the biological material surface, which causes collection and adherence of integrin-mediated leukocytes, release of cytokines and growth factors from adherent monocytes/macrophages, resulting in the occurrence of biomedicine material-related infection. To prevent the medical biological material-related inflammation, we should first embark from the material itself, and seek for some to respond the small medical material to the host inflammation.CONCLUSION: The success of material implantation depends on the medical biological material relevant inflammation. The production of biomaterial-related inflammation is action results of inflammatory cell, inflammation factor, complement as well as enzyme, oxygen free radical. Material surface microstructure, chemistry and dielectric and so on immediately influence inflammatory cells on material response.