强迫症和广泛性焦虑障碍患者注意网络功能比较

目的 探讨强迫症（obsessive-compulsive disorder,OCD）与广泛性焦虑障碍（generalized anxiety disorder,GAD）注意缺陷的特征.方法 对31例广泛性焦虑障碍患者（GAD组）、31例强迫症患者（OCD组）与30例健康对照组（HC组）采用注意网络测试（ANT）进行注意监测.结果 在注意网络功能测验中,OCD组、GAD组与HC组在警觉网络[（15.87±5.24）分,（26.77±4.33）分,（34.87±3.47）分]和执行控制网络[（114.84±9.64）分,（122.45±5.57）分,（96.57±5.45）分]差异有统计学意义（F=4.619,P=0.012; F=3.388,P=0.038）;组别间主效应差异有统计学意义（F=10.805,P=0.004）;各组之间反应时差异有统计学意义（F=19.808,P=0.000）,HC组反应时在不同线索之间差异有统计学意义（F=29.699,P=0.000）;相关研究显示警觉网络与HAMD存在显著负相关（r=-0.267）,执行控制网络与HAMA存在显著正相关（r=0.351）.结论 OCD组警觉网络存在损害,GAD组执行控制网络存在损害;注意和情绪的调节存在联系.

A study of attention networks in the patients with obsessive-compulsive disorder and generalized anxiety disorder

Objective To investigate the attention network in patients with obsessive-compulsive disorder （OCD） and generalized anxiety disorder （GAD）.Methods 31 GAD patients,31 OCD patients and 30 healthy controls （HC） were tested with attention network test.Results There were significant differences in the main effects with respect to the alerting network（15.87±5.24,26.77±4.33,34.87±3.47） （F=4.619,P=0.012）） and the executive network（114.84±9.64,122.45±5.57,96.57±5.45） （F=3.388,P=0.038） among the OCD,GAD and HC groups.The three groups did significantly differ in RT of the attention network （F=19.808,P=0.000）.For the HC group,there was significant main effects with respect to cue conditions（F=29.699,P=0.000）.There was a significant correlation between the executive network and Hamilton anxiety scale （r=0.351） and also a significantly negative correlation between the alerting network and Hamilton depression scale （r=-0.267）.Conclusion There are attention network damages in patients with OCD and GAD,which may be involved in the impairment of emotion.