腹腔镜与开腹手术治疗卵巢良性肿瘤对患者免疫功能的影响

目的探讨腹腔镜与开腹手术治疗卵巢良性肿瘤对患者免疫功能的影响。方法2009年1月至2013年1月收治的138例卵巢良性肿瘤患者,按照治疗方法分为腹腔镜组(68例)和开腹组(70例)。比较两组患者术中出血量、术后镇痛率、术后恢复排气时间、术后并发症发生率以及免疫功能。结果腹腔镜组患者的术中出血量、术后镇痛率、术后恢复排气时间及术后并发症发生率均明显低于开腹组,差异有统计学意义(P<0.05)。腹腔镜组患者术后24h CD+3T细胞比率、CD+4T细胞比率、CD+3T/CD+4T细胞比值明显高于开腹组,差异有统计学意义(P<0.05)。腹腔镜组术后24h IgG的水平明显高于开腹组患者,差异有统计学意义(P<0.05)。结论腹腔镜手术以其创伤小、术中出血量少、术后镇痛率低等优点成为治疗卵巢良性肿瘤的重要术式,同时可以较好地保护患者机体的细胞免疫和体液免疫功能,值得临床推广应用。

Effects of laparoscopic and laparotomy treatment on immune function in patients with ovarian benign tumor

Objective To investigate the effects on immune function of ovarian benign tumor treated with laparoscopic and laparotomy.Methods A retrospective analysis for clinical data of 138 patients with ovarian benign tumor between January 2009 and January 2013.The intraoperative blood loss,postoperative analgesia,postoperative recovery exhaust time and postoperative complication rates and Immune function were compared in two groups.Results The intraoperative blood loss,postoperative analgesia,postoperative recovery exhaust time and postoperative complication rates for patients with laparoscopic were significantly lower than laparotomy group（ P〈 0.05）,while the CD3^＋T cells,CD4^＋T cells,CD3^＋T / CD4^＋T cells expression was significantly higher than laparotomy group within 24 h after the operation（ P〈 0.05）.And the level of the IgG of laparoscopic group was obviously higher than that of laparotomy group（ P〈 0.05）.Conclusion Laparoscopic surgery was an important operation for treatment of ovarian benign tumor with small trauma,less intraoperative blood loss and lower postoperative analgesia rate,in the meantime,it was a good way to protect the patient＇s organism cellular immunity and humoral immunity functions,which was worthy of generalization in clinical application.