解脲支原体、沙眼衣原体感染与女性不孕症相关性的meta分析

目的:运用meta分析的方法探究女性不孕症与解脲支原体(Uu)和沙眼衣原体(Ct)感染之间的关系。方法:拟定严格的文献纳入标准和排除标准,检索中国知网以及维普、万方、中国生物医学文献数据库等中文数据库和PubMed等外文数据库,时间限定在2000~2014年。由两名研究者独立对检索后的文献进行质量评价,然后采用RevMan5.3软件对筛选出的文献进行数据定量分析。结果 :1共检索出相关文献181篇,其中中文文献132篇,英文文献49篇,仔细阅读相关文献的题目和摘要,对相关度高的文献详细阅读全文,严格依照以上的纳入和排除标准,最终共筛选出中文相关文献13篇,英文文献0篇,共纳入13个符合要求的研究,包含3760例患者;2将上述筛选后的文献进行meta分析,得出单纯Uu感染、单纯Ct感染以及两者混合感染合并后的OR分别为6.41(95%CI:4.85~8.47)、6.76(95%CI:5.33~8.58)、10.74(95%CI:6.87~16.81),各组与其相应对照组之间不孕症患病率差异均具有统计学意义。结论 :单纯的Uu或是Ct感染与女性不孕症相关,当两者混合感染时,女性患不孕症的危险度会更高,因此,在检测女性不孕症病因时,应该注重对Uu和Ct感染的检测。

A meta-analysis of ureaplasma urealyticum and chlamydia trachomatis infections with female infertility

Objective： To systematically evaluate associations between ureaplasma urealyticum （Uu） infection and chlamydia trachomatis （Ct） infection with female infertility. Methods： According to the strict inclusive and exclusive criteria, CNKI, CBMdisc, Wanfang, VIP and PubMed databases were searched. Furthermore, we manually searched the relevant references published from 2000 to 2014. Two reviewers selected trials and assessed trial quality independently by using the Cochrane Handbook 5.3. A meta--analysis was performed with the fix--effects model or random- effects model according to the heterogeneity. Results： A total of 181 relevant studies, involving 132 Chinese studies and 49 foreign studies were retrieved. Eventually, 13 eligible Chinese studies involving 3760 patients were included. The results of the meta--analysis were as follows： The merged odd ratio （OR） of Uu, Ct and （Uu ＋ Ct） were 6.41 （95 %00CI： 4.85--8.47）, 6.76 （95%CI： 5.33--8.58） and 10.74 （95%CI： 6.87--16.81）, respectively. The incidences of infertility in all groups were different when compared with the corresponding control groups. Conclusion.. There are significant associations between Uu and Ct infections with female infertility, suggesting that we should pay enough attention to the detection in infertile women with Uu and Ct infections.