精神分裂症患者幽默体验与心理理论的相关性

目的：探讨精神分裂症患者幽默体验能力及其与心理理论之间的关系。方法采用幽默图片测试（ HPT）、幽默视频测试（ HVT）以及心理理论故事图片任务（ ToM-PST）对61名精神分裂症患者和63名正常对照者进行评估。结果 HPT 中患者组非幽默图片等级总分[（28．41±11．56）分]高于正常组[（24．41±8．82）分]，幽默图片等级总分[（34．41±13．06）分]低于正常组[（45．65±11．49）分]，差异有统计学意义（P＜0．05）；HVT中患者组幽默视频等级均分[（2．46±0．79）分]、标准幽默时刻按键次数[（2．42±1．40）次]、标准幽默时刻敏感性d’（humor）分[（0．47±0．42）分]均低于正常组[分别为（3．56±0．57）分，（3．68±1．19）次，（1．11±0．46）分， P＜0．01]；患者组ToM-PST总分[（39．89±12．33）分]低于正常组[（58．76±0．64）分， P＜0．01]。相关分析显示，d’（ humor）分与阳性与阴性症状量表（ PANSS）总分（ r＝－0．380， P＜0．01）呈负相关。患者组非幽默图片等级总分与ToM-PST总分（ r＝－0．316， P＜0．05）呈负相关，d’（ humor）分与ToM-PST总分（ r＝0．400， P＜0．01）呈正相关。控制PANSS总分后，患者组d’（ humor）分与ToM-PST总分相关性仍具有统计学意义。结论精神分裂症患者幽默体验能力较差，这种幽默体验缺陷与患者心理理论损害存在关联，提示幽默体验与心理理论之间可能存在共同的神经心理基础。

A correlation study of humor experience and theory of mind in schizophrenia

Objective To explore humor experience and its relationship with theory of mind in patients with schizophrenia. Methods sixty-one schizophrenic patients without treatment and sixty-three healthy subjects were assessed with the Humor Picture Test （ HPT） ,Humor Video Test （ HVT） and the Theory-of-Mind Picture-Se-quencing Task （ ToM-PST） . Results Compared with healthy subject in HPT,schizophrenic patients showed sig-nificantly higher non-humor picture rating score （24.41 ± 8.82 vs 28.41 ± 11.56, P〈0.05）,and less humor picture rating score （45.65 ± 11.49 vs 34.41 ± 13.06, P〈0.05）. Compared with healthy subject in HVT,schizophrenic patients also showed significantly less humor video rating score （3.56 ± 0.57 vs 2.46 ± 0.79, P〈0.01） and the number of standard humorous moments （3.68 ± 1.19 vs 2.42 ± 1.40, P〈0.01） and the sensitivity of standard hu-morous moments-d’（humor） score （1.11 ± 0.46 vs 0.47 ± 0.42, P〈0.01）. Schizophrenic patients had significant-ly less total score （39.89 ± 12.33 vs 58.76 ± 0.64, P〈0.01） of ToM-PST compared to normal control. Correlation analysis showed a negative correlation between d’ （ humor） score and the Positive and Negative Syndrome Scale （ PANSS） total score （ r=-0.380, P〈0.01） for the patients. There was significantly negative correlation between non-humor picture rating score and ToM-PST total score （ r=-0.316, P〈0.05） ,and positive correlation between d’ （humor） score and ToM-PST total score （ r=0.400, P〈0.01） in schizophrenic patient. After controlling for the PANSS total score,the correlation between d’（humor） score and ToM-PST total score remained significant. Conclusion Schizophrenic patients have poor humor experience,which is related to the impairments of theory of mind.Humor experience deficit may share a common neuropsychological base with the impairment of theory of mind.