磁共振质子波谱和磁敏感对首发单相抑郁症患者海马组织代谢及回流静脉的联合分析

目的 联合磁敏感（SWI）及质子波谱（1H-MRS）两种手段对首发单相抑郁症患者海马部进行研究,探讨其变化规律及潜在联系.方法 对20例首发单相抑郁症患者及20例健康志愿者分别行SWI扫描及海马的1 H-MRS图像分析,对比分析其静脉系统及代谢指标的变化.结果 质子波谱分析显示抑郁组较对照组双侧海马部NAA/Cr（左侧海马：抑郁组0.95±0.77,对照组1.78±0.82;右侧海马：抑郁组1.12±0.74,对照组1.91±0.80）和Cho/Cr（左侧海马：抑郁组1.08±0.83,对照组1.75±0.73;右侧海马：抑郁组0.91±0.68,对照组1.95±0.74）显著降低,且差异有显著性（NAA/Cr：左右侧t值分别为-3.14、-3.49,均P＜0.05;Cho/Cr：左右侧t值分别为-3.25、-3.19,均P＜0.05）,而MI/Cr未见明显变化（左右侧t值分别为1.24、-1.27,P＞0.05）.磁敏感扫描显示抑郁组较对照组侧脑室下静脉直径、长度及分支数目显著减少（t值分别为3.23、4.56、2.66,均P＜0.05）.结论 SWI序列及1H-MRS两种影像手段可成为中枢核团研究的新思路,借助此思路或许可解释抑郁患者海马部血管异常和海马神经元代谢异常两者之间的潜在联系.

The combined analysis of susceptibility weighted imaging and proton spectroscopy sequence by high field magnetic resonance in the first-episode depression patients

Objective Combined with susceptibility weighted imaging （SWI） and proton magnetic resonance spectroscopy （1H-MRS） to study the hippocampus in the first-episode depression patients for exploring the causal relationship.Methods 20 first-episode depression patients and 20 healthy volunteers underwent SWI scanning and hippocampal 1H-MRS image,analysis and comparison the changes between the venous system and metabolism of two groups.Results Proton spectroscopy analysis showed that compared with the control group,bilateral hippocampal NAA/Cr（left hippocampus：depression group 0.95±0.77,control group 1.78±0.82; right hippocampus：depression group 1.12±0.74,control group 1.91 ± 0.80） and Cho/Cr （left hippocampus：depression group 1.08±0.83,control group 1.75±0.73 ; right hippocampus：depression group 0.91±0.68,control group 1.95 ±0.74） in the depression group was significantly lower,the difference was significant（NAA/Cr：t value in left and right were -3.14,-3.49,P〈0.05; Cho/Cr：t value in left and right were-3.25,-3.19,P〈0.05）,however MI/Cr had no obvious changes （t value in left and right were 1.24,-1.27,P〉0.05）.Magnetic sensitive scan showed depression group compared with the control group was significantly reduced in lateral vein diameter,length and branches （t value were 3.23,4.56,2.66,P〈0.05）.Conclusion The SWI sequence and 1H-MRS imaging methods can become a new research idea about the central nucleus,and this idea may explain the causal relationship between the hippocampus in depression patients of vascular abnormalities and hippocampal neuronal metabolic abnormalities.