中药减肥方联合针刺加运动对瘦体型多囊卵巢综合征患者内分泌指标及妊娠结局的影响

目的:研究中药减肥方联合针刺加运动对瘦体型多囊卵巢综合征(PCOS)患者内分泌指标及妊娠结局的影响。方法:将125例瘦体型PCOS患者随机分为两组。观察组采用中药减肥方联合针刺加运动治疗,对照组予以二甲双胍联合达英-35治疗,均为6个疗程。停药后随访6个月,比较两组治疗前后内分泌指标变化及妊娠结局。结果:治疗后两组患者卵巢体积,黄体生成激素(LH)、睾酮(T)、空腹胰岛素(FINS)、空腹血糖(FPG)水平及胰岛素抵抗指数(HOMA-IR)与治疗前相比差异均有统计学意义(P0.05);观察组和对照组排卵率分别为46.92%和32.26%,妊娠率分别为40.61%和30.16%,差异均无统计学意义(P0.05)。结论:中药减肥方联合针灸加运动治疗瘦体型PCOS,在改善IR、降低T、促进排卵、增加妊娠率等方面,与二甲双胍联合达英-35疗效相当。

The effect of weight-loss herbal decoction combined with acupuncture and exercise on endocrine markers and pregnancy outcomes in non-obesity patients with polycystic ovary syndrome

Ohjective： To investigate the effect of weight-loss herbal decoction combined with acupuncture and exercise on endocrine markers and pregnancy outcomes in non-obesity polycystic ovary syndrome （PCOS） patients with deficiency of Qi and blood stasis. Methods： A total of 125 non-obesity PCOS patients were randomly divided into two groups. Weight-loss herbal decoction combined with acupuncture and exercise was given to the study group and dimethylbiguanide plus Diane-35 was given to the controls for 6 courses, respectively. A 6-month follow-up was conducted after treatment discontinued, endocrine markers pre-and post-treatment and pregnant outcomes were compared. Results： The ovarian size, serum luteinizing hormone （LH）, testosterone （T）, fasting insulin （FINS）, fasting blood sugar （FBS） and homeostatic model assessment for insulin resistance （HOMA-IR） levels were significantly decreased in both groups post-treatment （P〈0.05） with no statistical difference between groups （P 〉0.05）. Rates of ovulation and pregnancy were 46.92% and 40.61% in the study group, 32.26 % and 30.16% in the control group, showing no significant statistical differences between groups （P〉0.05）. Conclusion： Weight-loss herbal decoction combined with acupuncture and exercise has similar therapeutic effect with dimethylbiguanide plus Diane-35 in aspect of improving IR, decreasing T concentration, facilitating ovulation and increasing the pregnancy rate in non-obesity PCOS patients.