补肾调经方药对肾虚型排卵障碍者治疗效果分析

目的:利用补肾调经中药治疗肾虚型排卵障碍评估中医"从肾论治"的效果。方法:采用自身对照和组间对照的方法,对167例排卵障碍性不孕妇女进行3个治疗周期和3个随访周期的观察,服用克罗米芬(西药组)55例,服用克罗米芬和补肾调经方药(中西药组)112例。结果:治疗后,肾虚型临床自觉症状表现总有效率中西药组(83.0%)高于西药组(43.6%)(P0.01),总妊娠率中西药组(69.6%)高于西药组(41.8%)(P0.01),周期妊娠率中西药组(23.0%)高于西药组(14.2%)(P0.05),月经周期正常者中西药组(82.0%)高于西药组(71.1%)(P0.05),排卵障碍表现者中西药组(25.9%)低于西药组(44.7%)(P0.01),在LH-6~LH+1子宫内膜发育中西药组均好于西药组(P0.05~0.01)。结论:补肾调经方药具有明确的调经、促排卵、健内膜作用,体现出中医药"从肾论治"思想的优势。

Effect of Bushen Tiaojing Decoction on nephrasthenia anovulatory infertility

Objective： To evaluate the effect of ＂treatment from kidney＂ by evaluating the effect of Bushen Tiaojing De- coction on nephrasthenia anovulatory infertility. Methods： By using a case-control and self-control study, 167 women with nephrasthenia anovulatory infertility were recruited for three treatment cycles and 3 follow-up cycles. Fifty-five women in the western medicine group took clomiphene citrate, and 112 women in the traditional Chinese and western medicine group were treated with clomiphene and Bushen Tiaojing recipe. Results： The degree of improvement of the clinical signs and symptoms in the traditional Chinese and western medicine group （83.0%） was significantly higher than that of the western medicine group （43.6%, P〈0.01）, the total pregnancy rate in the traditional Chinese and western medicine group （69.6%） was significantly higher than that of the western medicine group （41.8%, P〈 0.01）, the pregnancy rate per cycle （23.0%） in the traditional Chinese and western medicine group was significantly higher than that of the western medicine group （14.2%, P〈0.05）, the percentage of women with normal menstrual cycle （82.0 %） in the traditional Chinese and western medicine group was significantly higher than that of the western medicine group （71.1%, P〈0.05）, and the percentage those with ovulation disorder in the traditional Chinese and western medicine group （25.9 % ） was significantly lower than that of the western medicine group （44.7 %, P 〈0.01）, and the endometrial developments on the day of LH-6 to LH ＋ 1 in the traditional Chinese and western medicine group were significantly better than those of clomiphene group （P〈 0.05 to〈 0.01）. Conclusion： Bushen Tiaojing recipe plays a role in the physiological processes of menstruation, ovulation, endometrial rehabilitation, showing the advantage of ＂treatment from kidney＂ with traditional Chinese medicine.