Role of protein synthesis in the replication of the killer virus of yeast |
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| Authors: | Michael J Leibowitz |
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| Institution: | (1) Department of Microbiology, University of Medicine and Dentistry of New Jersey, Rutgers Medical School, 08854 Piscataway, New Jersey, USA |
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| Abstract: | Summary Growth of yeast in the presence of the protein synthesis inhibitors cycloheximide and cryptopleurine results in elimination ( curing ) of the cytoplasmically-inherited killer virus. Yeast mutants with ribosomal subunits resistant to the translational effects of one of these antibiotics are specifically resistant to curing by that antibiotic, indicating that these substances act on the virus by their effect on protein synthesis. |
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| Keywords: | Killer virus Cycloheximide Cryptopleurine |
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