Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study

Authors:	Annica Lindkvist Arvid Edén Melissa M Norstr?m Veronica D Gonzalez Staffan Nilsson Bo Svennerholm Annika C Karlsson Johan K Sandberg Anders S?nnerborg Magnus Gisslén

Affiliation:	(1) Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden;(2) Department of Infectious Diseases, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden;(3) The Swedish Institute for Infectious Disease Control, Solna, Sweden;(4) Department of Microbiology Tumour and Cell Biology MTC, Karolinska Institute, Stockholm, Sweden;(5) Center for Infectious Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden;(6) Department of Mathematical Statistics, Chalmers University of Technology, Gothenburg, Swedenc;(7) Department of Clinical Virology, University of Gothenburg Sahlgrenska University Hospital, Gothenburg, Sweden;(8) Department of Infectious Diseases, Karolinska Institute, Stockholm, Sweden

Abstract:	Background The latency of HIV-1 in resting CD4⁺ T-lymphocytes constitutes a major obstacle for the eradication of virus in patients on antiretroviral therapy (ART). As yet, no approach to reduce this viral reservoir has proven effective.

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