护肝宁片治疗非酒精性脂肪肝疗效观察

[目的]观察护肝宁片治疗非酒精性脂肪肝(NASH)的疗效.[方法]将165例NASH患者随机分为治疗组(110例)和对照组(55例),分别应用护肝宁片和硫普罗宁片治疗.观察两组患者治疗前及治疗6、12周时,肝功能及血脂指标的变化.[结果]两组患者治疗后的肝功能及血脂指标与治疗前比较均得到明显改善(P＜0.05);在治疗后6周及12周时,治疗组与对照组肝功能指标的比较差异无统计学意义(P＞0.05);治疗组治疗后12周时,三酰甘油(TG)降低,与对照组比较差异有统计学意义(P＜0.05).[结论]护肝宁片治疗NASH疗效明显,显著改善患者肝功能;且降低TG的疗效及安全性优于硫普罗宁片,值得临床上推广应用.

Therapeutic effects of Huganning pill on patients with nonalcoholic steatohepatitis

[Objective] To observe the therapeutic effects of Huganning pill on the patients with nonalcoholic steatohepatitis.[Methods] One hundred and sixty-five patients with nonalcoholic steatohepatitis(NASH)were selected and divided randomly into two groups: treated group(n=110) and control group(n=55),which were treated with Huganning pill and tiopronin tablets respectively.Before and after treatment for 6 and 12 weeks,the parameters of liver function and blood fat were detected for the patients of both groups.[Results] The parameters of liver function and blood fat in the patients of both groups were all improved obviously after treatment compared with pretherapy(P<0.05).In 6 and 12 weeks of post-treatment,the improvement of liver function in the patients of treated group had no significant difference compared with control group(P>0.05).In 12 weeks of post-treatment,the decrease of triglyeride in the patients of treated group had a significant difference compared with control group(P<0.05).[Conclusion]It has been suggested that Huganning pill has significant therapeutic effects on nonalcoholic steatohepatitis.Huganning pill improves liver function obviously,and its therapeutic effect of decreasing triglyeride is more excellent compared with tiopronin.Huganning pill has no side effects in the course of treatment,and is worth further application in clinic.