| TGF-β和P53在肾细胞癌中的表达及意义 |
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| 引用本文： | 吴小燕,付君静,曾俊.TGF-β和P53在肾细胞癌中的表达及意义[J].武汉大学学报(医学版),2007,28(5):584-587,I0002. |
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| 作者姓名： | 吴小燕 付君静 曾俊 |
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| 作者单位： | 武汉大学中南医院内科,湖北,武汉,430071;武汉大学中南医院内科,湖北,武汉,430071;武汉大学中南医院内科,湖北,武汉,430071 |
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| 基金项目： | 湖北省科技厅科技攻关项目 |
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| 摘 要： | 目的:通过检测转化生长因子-β(TGF-β)和P53在肾细胞癌(RCC)中的表达,探讨它们与肾癌的发生、病理分级、临床分期的关系。方法:免疫组织化学方法检测40例RCC石蜡标本中TGF-β和P53的蛋白表达,并分组进行统计学分析。结果:TGF-β与P53在RCC中表达率与对照组相比明显升高(P<0.05),但不同病理分级、临床分期之间差异无显著性(P>0.05)。TGF-β和P53表达存在正性相关,但两者在RCC中表达率存在显著性差异,TGF-β表达率高于P53的表达率(P<0.05)。结论:TGF-β和P53高表达可能成为肾癌的恶性表型之一,但两者与病理分级、临床分期无明显相关性。它们可能单独或协同作用调节细胞生长和转化,促进肾癌的发生。
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| 关 键 词： | 肾细胞癌 转化生长因子-β P53 免疫组化 |
| 文章编号： | 1671-8852（2007）05-0584-04 |
| 修稿时间： | 2007-04-09 |
Expression of TGF-beta and P53 in Renal Cell Carcinoma |
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| WU Xiaoyan,FU Junjing,ZENG Jun.Expression of TGF-beta and P53 in Renal Cell Carcinoma[J].Medical Journal of Wuhan University,2007,28(5):584-587,I0002. |
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| Authors: | WU Xiaoyan FU Junjing ZENG Jun |
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| Institution: | Dept. of Internal Medicine ,Zhongnan Hospital of Wuhan University ,Wuhan 430071 ,China |
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| Abstract: | Objective: To investigate the expression of transforming growth factorβ(TGF-β)and P53 in renal cell carcinoma(RCC).Methods: Protein expression of TGF-β and P53 in 40 RCC tissues was examined by immunohistochemical assay.Results: TGF-β and P53 showed an overexpression rate in RCC,but there were no significant differences among different pathological grades and clinical stages.A positive correlation was detected between TGF-β and P53,but the expression rate of TGF-β was higher than that of P53.Conclusion: Both the expression of TGF-β and P53 were malignant phenotypes in RCC,but there are no correlation at different pathological grades and clinical stages.Both may regulate cell growth and transformation for the occurrence of RCC solely or cooperatively. |
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| Keywords: | Renal Cell Carcinoma Transforming Growth Factorβ P53 Immunohistochemistry |
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