动态反应池电感耦合等离子体质谱法快速监测人体尿液中19种元素的含量

目的利用DRC-ICP-MS,建立快速监测尿液中19种元素(Be、Rb、Sr、Cd、Pb、Cs、Tl、V、Cr、Mn、Ni、Co、Cu、Zn、Sn、Sb、Te、As和Se)的检测方法。方法尿液样品经过1∶20稀释后上机检测,采用DRC模式消除干扰,检测元素V51、Cr52、Mn55、Ni58、Co59、Cu63、Zn64、Sn120、Sb121、Te130、As75和Se80,其余元素采用标准模式检测。结果 19种元素(Be9、V51、Cr52、Mn55、Ni58、Co59、Cu63、Zn64、As75、Se80、Rb85、Sr88、Cd114、Sn120、Sb121、Te130、Cs133、Tl205和Pb208)的方法检出限分别为2.7、2.0、2.7、1.5、3.9、0.8、5.8、35.3、32.4、21.1、1.4、4.2、1.1、9.1、1.1、8.6、0.1、0.2和1.0ng/L,方法的精密度在3%以内。结论该检测方法准确快速,前处理简便,样品用量少,检测成本低,适合大量样本的快速筛查和监测。

Rapid determination of 19 elements in human urine by inductively coupled plasma-mass spectrometry with dynamic reaction cell

Objective A simple method is proposed for determination of Be,Rb,Sr,Cd,Pb,Cs,Tl,V,Cr,Mn,Ni,Co,Cu,Zn,Sn,Sb,Te,As and Se in urine by using inductively coupled plasma mass spectrometry with dynamic reaction cell.Methods Prior to analysis,samples were diluted(1∶20) in a solution of nitric acid(3%,V/V).The DRC mode was applied to determine the content of V51,Cr52,Mn55,Ni58,Co59,Cu63,Zn64,Sn120,Sb121,Te130,As75 and Se80.For the other elements,the instrument was operated in standard mode.Results The method detection limits were 2.7ng/L for Be9,2.0ng/L for V51,2.7ng/L for Cr52,1.5ng/L for Mn55,3.9ng/L for Ni58,0.8ng/L for Co59,5.8ng/L for Cu63,35.3ng/L for Zn64,32.4ng/L for As75,21.1ng/L for Se80,1.4ng/L for Rb85,4.2ng/L for Sr88,1.1ng/L for Cd 9.1ng/L for Sn120,1.1ng/L for Sb121,8.6ng/L for Te130,0.1ng/L for Cs133,0.2ng/L for Tl205 and 1.0ng/L for Pb208.The precisions of the method were in the range of 0.3%～2.6%.Conclusion The proposed method was rapid,accurate and can be used for measurement with simple pre-treatment,less sample and lower cost.The method was also suitable for massive samples in screening and monitoring.