| 复方甲地孕酮微囊注射液对大鼠下丘脑弓状核超微结构的影响 |
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| 引用本文： | 陈文玉,欧可群.复方甲地孕酮微囊注射液对大鼠下丘脑弓状核超微结构的影响[J].解剖学杂志,1994,17(1):29-36. |
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| 作者姓名： | 陈文玉 欧可群 |
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| 作者单位： | 华西医科大学组织学与胚胎学教研室 成都610041(陈文玉，欧可群，马玉琼，陈思秀)，华西医科大学妇产科学教研室 成都610041(韩字研) |
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| 摘 要： | 用不同剂量的复方甲地孕酮微囊针剂注射大鼠，观察其下丘脑弓状核超微结构变化，结果显示：实验组有部暗细胞的粗面内质网及高尔基器囊扩大，囊内有低电子密度絮状物，神经分泌颗粒增多，部分亮细胞质内参与分泌颗合成的细胞器减少；０．４ｍｌ组次级溶酶体数量和弓状核细胞体上含颗粒囊泡的轴体突触数目均增加，该两项分别与对照组比较，差异有显著性（Ｐ值均＜０．０１）。
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| 关 键 词： | 甲地孕酮 弓状核 轴体突触 大鼠 |
AN OBSERVATION ON THE EFFECT OF THE INJECTION OF MICROENCAPSULATED COMPOUND MEGESTROL ACETATE ON THE ULTRASTRUCTURE OF RAT ACETATE HYPOTHALAMIC NUCLEUS |
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| Chenn Wenyu,Ou Kequn. Ma Yuqiong,Chen Sixiou,Han Ziyan.AN OBSERVATION ON THE EFFECT OF THE INJECTION OF MICROENCAPSULATED COMPOUND MEGESTROL ACETATE ON THE ULTRASTRUCTURE OF RAT ACETATE HYPOTHALAMIC NUCLEUS[J].Chinese Journal of Anatomy,1994,17(1):29-36. |
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| Authors: | Chenn Wenyu Ou Kequn Ma Yuqiong Chen Sixiou Han Ziyan |
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| Institution: | Chenn Wenyu,Ou Kequn. Ma Yuqiong,Chen Sixiou,Han Ziyan Department of Histology and Embryology. Department of Obstetrics and Gynecology.West China University of Medical Sciences,Chengdu 610041 |
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| Abstract: | We observed the changes of the ultrastructure of the Arcuate Hypothalamic Nucleus after intramuscular injections with different doses of microencapsulated compound megestrol acetate into rats. It was found under the electron microscope that the rouhg surfaced endoplasmic reticulum (RER) and Golgi complex were dilated, in which catkin contents were deposited. Neurocrine gran-ules in the part of the dark cells increased, while organelles, responsible for synthesizing and se-creting granules, in the pan of light cells decreased. The amount of lysosomes and axo-somatic synapses-containing granular vesicles in the cells increased in 0.4ml experimental group, and there was a statistically significant difference (p<0.01), compared with the control group. |
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| Keywords: | injection of microencapsulated compound megestrol acetate arcuate nucleus axosomatic synapse rat |
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