丁二酸洛沙平与利培酮治疗精神分裂症对照研究

目的：评价丁二酸洛沙平与利培酮治疗精神分裂症的疗效和不良反应。方法：将精神分裂症住院患者41例随机分为洛沙平和利培酮治疗组治疗6周。分别于治疗前、治疗3周及6周评定阳性与阴性症状量表（PANSS）、治疗中出现的症状量表（TESS）。结果：洛沙平和利培酮治疗组临床缓解率分别为58%和64%,差异无显著性（P〉0.05）,于治疗6周洛沙平对阴性症状的疗效优于利培酮（P〈0.05）。不良反应发生率与利培酮相当。结论：丁二酸洛沙平疗效与利培酮相当,特别是对阴性症状疗效更好。

Comparative study between loxapine and risperdal in the treatment of schizophrenia

Objective: To evaluate the therapeutic efficacy and side effects of loxapine and risperdal in the treatment of schizophrenia. Method:Forty-one patients of schizophrenia were treated with loxapine or risperdal randomly for six weeks.The positive and negative symptoms scale (PANSS) and the treatment emergent symptom scale (TESS) were used before and after 3 and 6 weeks treatment. Results:According to the scores of PANSS,the clinical remission rate in loxapine group and risperdal group were 58% and 64% respectively,and there was no significant difference between the two groups.At the end of 6th week treatment,the improvement of negative symptoms was more obvious in loxapine group than in risperdal group (P<0.05).The side effects of loxapine were similar to those of risperdal. Conclusion: Loxapine has similar efficacy to risperdal in the treatment of schizophrenia,and is especially better in improving the negative symptoms.