Antifungal Activity of 10 Guadeloupean Plants |
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| Authors: | Murielle Biabiany Vincent Roumy Thierry Hennebelle Nadine François Boualem Sendid Muriel Pottier El Moukhtar Aliouat Isabelle Rouaud Françoise Lohézic‐Le Dévéhat Henry Joseph Paul Bourgeois Sevser Sahpaz François Bailleul |
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| Institution: | 1. UDSL, EA4481 GRIIOT, Laboratoire de Pharmacognosie, Université Lille Nord de France F‐59000 Lille, Faculté de Pharmacie, , France;2. APLAMEDAROM, Association des Plantes Médicinales et Aromatiques de Guadeloupe, Mompierre, , 97111 Morne‐à‐l'eau, Guadeloupe, France;3. UDSL, Inserm U799, Laboratoire de Mycologie Fondamentale et Appliquée, , F‐59045 Lille, France;4. Biology and Diversity of Emerging Eukaryotic Pathogens (BDEEP), Centre for Infection and Immunity of Lille (CIIL);5. Inserm U1019, CNRS UMR 8204, Université Lille Nord de France", , 59019 Lille, France;6. Institut de Chimie de Rennes, UMR CNRS 6226, , F‐35043 Rennes, France |
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| Abstract: | Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection Pneumocystis pneumonia. For the first time, the CMI of these plant extracts cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five Candida species, Scytalidium dimidiatum, a Malassezia sp. strain and Pneumocystis carinii. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of Bursera simaruba, Cedrela odorata, Enterolobium cyclocarpum and Pluchea carolinensis have interesting activities and could be good candidates for developing antifungal formulations. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | antifungal extract Pneumocystis Bursera Cedrela Enterolobium Pluchea |
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