Pharmacokinetic interaction between methotrexate and chloral hydrate |
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| Authors: | Kim Dao MD Anton Ivanyuk MD Thierry Buclin MD Maja Beck‐Popovic MD Manuel Diezi MD |
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| Affiliation: | 1. Division of Clinical Pharmacology, Biomedicine, Department of Laboratories, CHUV, Lausanne, Switzerland;2. Department of Pediatrics, CHUV, Pediatric Hemato‐Oncology Unit, Lausanne, Switzerland |
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| Abstract: | We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high‐dose chemotherapy when co‐administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion. Pediatr Blood Cancer 2013; 60: 518–520. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | cell lymphoblastic leukemia– lymphoma chloral hydrate drug interactions methotrexate precursor |
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