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A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors |
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| Authors: | Changho Choi Sandeep Ganji Keith Hulsey Akshay Madan Zoltan Kovacs Ivan Dimitrov Song Zhang Kumar Pichumani Dianne Mendelsohn Bruce Mickey Craig Malloy Robert Bachoo Ralph DeBerardinis Elizabeth Maher |
| Affiliation: | 1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, , Dallas, TX, USA;2. Department of Radiology, University of Texas Southwestern Medical Center, , Dallas, TX, USA;3. Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, , Dallas, TX, USA;4. Philips Medical Systems, , Cleveland, OH, USA;5. Department of Clinical Sciences, University of Texas Southwestern Medical Center, , Dallas, TX, USA;6. Annette Strauss Center for Neuro‐Oncology, University of Texas Southwestern Medical Center, , Dallas, TX, USA;7. Department of Neurological Surgery, University of Texas Southwestern Medical Center, , Dallas, TX, USA;8. Department of Internal Medicine, University of Texas Southwestern Medical Center, , Dallas, TX, USA;9. Veterans Affairs North Texas Health Care System, , Dallas, TX, USA;10. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, , Dallas, TX, USA;11. Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, , Dallas, TX, USA;12. McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, , Dallas, TX, USA |
| Abstract: | 2‐Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The 1H resonances of the J‐coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point‐resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25‐ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH‐mutated gliomas. The results indicate that TE = 97 ms provides higher detectability of 2HG than TE = 35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses. Copyright © 2013 John Wiley & Sons, Ltd. |
| Keywords: | 2‐hydroxyglutarate (2HG) 1H MRS 3 T point‐resolved spectroscopy (PRESS) short/long TE volume‐localized simulations human brain IDH‐mutated gliomas |