Doubly selective multiple quantum chemical shift imaging and T1 relaxation time measurement of glutathione (GSH) in the human brain in vivo |
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| Authors: | In‐Young Choi Phil Lee |
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| Institution: | 1. 913‐588‐0174913‐588‐9071;2. Hoglund Brain Imaging Center, University of Kansas Medical Center, , Kansas City, KS, 66160 USA;3. Department of Neurology, University of Kansas Medical Center, , Kansas City, KS, 66160 USA;4. Department of Molecular & Integrative Physiology, University of Kansas Medical Center, , Kansas City, KS, 66160 USA;5. The Nathan Kline Institute, Medical Physics, , Orangeburg, NY, 10962 USA |
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| Abstract: | Mapping of a major antioxidant, glutathione (GSH), was achieved in the human brain in vivo using a doubly‐selective multiple quantum filtering based chemical shift imaging (CSI) of GSH at 3 T. Both in vivo and phantom tests in CSI and single voxel measurements were consistent with excellent suppression of overlapping signals from creatine, γ‐Amino butyric acid (GABA) and macromolecules. GSH concentration in the fronto‐parietal region was 1.20 ± 0.16 µmol/g (mean ± SD, n = 7). The longitudinal relaxation time (T1) of GSH in the human brain was 397 ± 44 ms (mean ± SD, n = 5), which was substantially shorter than that of other metabolites. This GSH‐CSI method permits us to address regional differences of GSH in the human brain under conditions where oxidative stress has been implicated, including multiple sclerosis, aging and neurodegenerative diseases. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | glutathione human brain in vivo multiple quantum filtered CSI longitudinal relaxation time (T1) of glutathione |
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