In Vitro Antibacterial Activity and Synergistic Antibiotic Effects of Phlorotannins Isolated from Eisenia bicyclis Against Methicillin‐Resistant Staphylococcus aureus |
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| Authors: | Sung‐Hwan Eom Do‐Hyung Kim Sang‐Hoon Lee Na‐Young Yoon Ji Hoe Kim Tae Hoon Kim Yong‐Hyun Chung Seon‐Bong Kim Young‐Man Kim Hyun‐Woo Kim Myung‐Suk Lee Young‐Mog Kim |
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| Affiliation: | 1. Department of Food Science and Technology, Pukyong National University, , Busan, 608‐737 Republic of Korea;2. Korea Food Research Institute, , Sungnam‐Si, Gyeonggi‐Do, 463‐746 Republic of Korea;3. Food Safety Research Division, National Fisheries Research & Development Institute, , Busan, 619‐705 Republic of Korea;4. Department of Herbal Medicinal Pharmacology, Daegu Haany University, , Gyeongsan, 712‐715 Republic of Korea;5. Department of Ecological Engineering, Pukyong National University, , Busan, 608‐737 Republic of Korea;6. Department of Food and Nutrition, Dong‐eui University, , Busan, 614‐714 Republic of Korea;7. Department of Marine Biology, Pukyong National University, , Busan, 608‐737 Republic of Korea;8. Department of Microbiology, Pukyong National University, , Busan, 608‐737 Republic of Korea |
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| Abstract: | Six phlorotannins, isolated from Eisenia bicyclis, were evaluated for antibacterial activity against methicillin‐resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) of the compounds were in the range 32 to 64 µg/mL. Phlorofucofuroeckol‐A (PFF) exhibited the highest anti‐MRSA activity, with an MIC of 32 µg/mL. An investigation of the interaction between these compounds and the β‐lactam antibiotics ampicillin, penicillin, and oxacillin revealed synergistic action against MRSA in combination with compound PFF. To our knowledge, this is the first report on the anti‐MRSA activity of phlorotannins from E. bicyclis. The results obtained in this study suggest that the compounds derived from E. bicyclis can be a good source of natural antibacterial agents against MRSA. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | antibacterial activity Eisenia bicyclis methicillin‐resistant Staphylococcus aureus phlorotannins |
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