Langerhans cell histiocytosis (LCH): Guidelines for diagnosis,clinical work‐up,and treatment for patients till the age of 18 years |
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| Authors: | Riccardo Haupt MD Milen Minkov MD Itziar Astigarraga MD Eva Schäfer MSc Vasanta Nanduri MD Rima Jubran MD R. Maarten Egeler MD PhD Gritta Janka MD Dragan Micic MD Carlos Rodriguez‐Galindo MD Stefaan Van Gool MD Johannes Visser MBChB Sheila Weitzman MD Jean Donadieu MD PhD for the Euro Histio Network |
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| Affiliation: | 1. Department of Hematology and Oncology, Epidemiology and Biostatistics Section, Istituto G. Gaslini, Genova, Italy;2. Children's Cancer Research Institute, St. Anna Children's Hospital, Vienna, Austria;3. Hospital Universitario Cruces Barakaldo, Barakaldo, Spain;4. Reference Centre for Histiocytosis at Hopital Trousseau, Assistance Publique – Hopitaux de Paris, France;5. Watford General Hospital, Watford, UK;6. Children's Hospital of Los Angeles, Los Angeles, California;7. Hospital for Sick Children, Toronto, Ontario, Canada;8. University Medical Center Hamburg‐Eppendorf, Hamburg, Germany;9. Mother and Child Health Institute of Serbia “Dr Vukan Cupic,” Belgrade, Serbia;10. Dana Farber Cancer Institute, Children's Hospital Boston, Boston, Massachusetts;11. University Hospital Gasthuisberg, Leuven, Belgium;12. University Hospitals of Leicester, Leicester Children's Hospital, Leicester, UK |
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| Abstract: | These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work‐up, and treatment and long‐term follow‐up of LCH patients are presented. Pediatr Blood Cancer 2013;60:175–184. © 2012 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. |
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| Keywords: | clinical work‐up diagnosis follow‐up guidelines Langerhans cell histiocytosis therapy |
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