Successful liver transplantation in an infant with stage 4S(M) neuroblastoma |
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| Authors: | Melanie Steele Nicola L. Jones MD FRCPC PhD Vicky Ng MD FRCPC Binita Kamath MBBChir Yaron Avitzur MD Rose Chami MD Ernest Cutz MD FRCPC Annie Fecteau MDCM MHSc MSc Sylvain Baruchel MD |
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| Affiliation: | 1. McMaster University, Michael G. DeGroote School of Medicine, Hamilton, Canada;2. Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada;3. Division of Gastroenterology, Hepatology and Nutrition, Liver Transplant Program, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada;4. Division of Pathology, The Hospital for Sick Children, Toronto, Canada;5. Liver Transplant Program, Division of General Surgery, The Hospital for Sick Children, Toronto, Canada;6. Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada |
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| Abstract: | We report a 2.5‐month‐old infant with bilateral adrenal neuroblastoma, stage 4S(M), with liver metastases and chemotherapy‐induced veno‐occlusive disease leading to cirrhosis requiring liver transplantation. Despite unknown tumour histology and MYCN‐amplification status, we proceeded with liver transplant. This decision was based on clinical suspicion that our patient was MYCN‐negative due to significant tumour regression, and was supported by evidence indicating that MYCN‐amplification is rare in infants with favourable‐stage neuroblastoma. This is the second case report of neuroblastoma requiring liver transplantation; however, in the previously reported case, the diagnosis of neuroblastoma was not established until after transplantation. We discuss this unique case to justify the potential use of life‐saving liver transplants in infants with neuroblastoma. Pediatr Blood Cancer 2013; 60: 515–517. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | bilateral adrenal neuroblastoma liver transplantation stage 4S MYCN amplification veno‐occlusive disease |
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