Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosis |
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| Authors: | Ulrike Zeilhofer MD Michael Ashworth MD FRCPath Persis Amrolia FRCP FRCPath Anupama Rao MD MRCPath Robert Chiesa MD Paul Veys FRCP FRCPath Kanchan Rao MD MRCP |
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| Affiliation: | 1. Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom;2. Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom;3. Department of Hematology, Great Ormond Street Hospital, London, United Kingdom |
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| Abstract: | We report two children who developed severe, fatal pulmonary hypertension (PHT) after mismatched unrelated donor cord blood transplantation using reduced intensity conditioning for HLH. PHT was diagnosed on post mortem lung biopsies with no evidence of HLH, pulmonary veno‐occlusive disease, infection or of idiopathic pulmonary hypertension. PHT may be an association with HLH and physicians treating HLH should be aware of this potential association. Pediatr Blood Cancer 2013; 60: 521–523. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | HLH pulmonary hypertension transplantation |
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