温针灸联合益气滋阴方治疗糖尿病周围神经病变及对患者氧化应激水平及神经电生理的影响

目的:探究温针灸联合益气滋阴方对糖尿病周围神经病变(DPN)患者氧化应激水平及神经电生理的影响,为DPN患者的诊疗提供指导依据.方法:60例DPN患者为研究对象,按照随机数字表法,将60例患者分成观察组和对照组各30例.对照组在常规降糖基础上给予依帕司他片口服治疗,观察组在对照组的基础上,给予温针灸和益气滋阴方治疗.比...

Effect of warming needle moxibustion combined with Yiqi Ziyin decoction on oxidative stress level and nerve electrophysiology in patients with diabetic peripheral neuropathy

Objective:Explore the effects of warming acupuncture and moxibustion combined with Yiqi Ziyin decoction on oxidative stress levels and neuroelectrophysiology in patients with diabetic peripheral neuropathy(DPN),and provide guidance for the diagnosis and treatment of patients with DPN.Methods:The 60 patients with DPN were prospectively selected as the research objects.According to the random number table method,60 patients were divided into observation group(n=30)and control group(n=30).The control group was given oral metformin hydrochloride treatment,and the observation group was given warm needle moxibustion and Yiqi Ziyin decoction on the basis of the control group.Compare the toronto clinical scoring system and the lower limb nerve conduction velocity,serum superoxide dismutase and malondialdehyde and other oxidative stress indicators of the two groups before and after treatment,and observe EMG curative effect in the two groups.The random walking model was used to evaluate the oxidative stress level and neuro-electrophysiological improvement of the two groups of patients after treatment.Results:Before treatment,the comparison of TCSS scores,MCV,SCV,SOD,and MDA levels between the two groups of patients was not statistically significant(P>0.05),and they were significantly improved after treatment(P<0.05);after treatment,the observation group patients’TCSS scores,fasting blood glucose,2 h postprandial blood glucose,total cholesterol,triglycerides,low-density lipoprotein,and MDA levels were significantly reduced,and high-density lipoprotein motor nerve conduction velocity,sensory nerve conduction velocity,treatment effective rate,and SOD level increased significantly(P<0.05).The results of the random walking model showed that the comprehensive improvement rates of SOD,MDA,MCV,and SCV were 11.2%,15.3%,10.5%,and 14.3%for each forward step in the control group.For each forward step in the observation group,SOD,MDA,the comprehensive improvement rates of MCV and SCV were 17.3%,26.5%,16.1%,25.6%,respectively.The observation group improved significantly compared with the control group.Conclusion:Warming needle moxibustion combined with Yiqi Ziyin decoction can effectively treat DPN,especially for nerve conduction and oxidative stress.This method is worthy of clinical reference.