| G蛋白偶联受体在肾脏疾病中的作用机制研究进展 |
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| 引用本文： | 王晓杰,崔晓阳,褚晴晴,李羽佳,吕航,易凡. G蛋白偶联受体在肾脏疾病中的作用机制研究进展[J]. 生物医学转化, 2022, 3(2): 39-45 |
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| 作者姓名： | 王晓杰 崔晓阳 褚晴晴 李羽佳 吕航 易凡 |
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| 作者单位： | 山东大学基础医学院,山东 济南 250012 |
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| 基金项目： | 国家自然科学基金(82030024;81720108007);国家重点研发计划(2018YFC1314000) |
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| 摘 要： | 细胞外囊泡 (Extracellular Vesicles,EVs) 是由细胞分泌的脂质双分子层结构,是介导细胞间通讯的重要媒介, 参与了多种肾脏病的发生发展。近年来,越来越多的研究显示,尿液EVs携带有肾脏固有细胞来源的蛋白质和核酸,可成为肾脏病诊断标志物的重要来源。此外,EVs作为机体内天然的递送载体,具有良好的生物相容性和低免疫原性,为肾脏病治疗提供了新的策略。本文综述EVs在肾脏病诊断和治疗中的作用研究进展。
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| 关 键 词： | G蛋白偶联受体 肾脏疾病 黏附类G蛋白偶联受体 大麻素受体 溶血磷脂酸受体 |
Recent advances on the role of G-protein-coupled receptors in kidney diseases |
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| Wang Xiaojie,Cui Xiaoyang,Chu Qingqing,Li Yuji,Lu Hang,Yi Fan. Recent advances on the role of G-protein-coupled receptors in kidney diseases[J]. Biomedical Transformation, 2022, 3(2): 39-45 |
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| Authors: | Wang Xiaojie Cui Xiaoyang Chu Qingqing Li Yuji Lu Hang Yi Fan |
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| Affiliation: | Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing 210009 , Jiangsu, China |
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| Abstract: | The G-protein-coupled receptors (GPCRs) are widely expressed in many cell types and participate in various cellular biological processes. Several studies have shown that GPCRs-mediated signaling pathways play significant roles in maintaining renal development, regulating renal physiological function, and in the pathogenesis of renal diseases. In this review, we have described the characteristics and function of GPCRs-related pathways, especially the adhesion GPCRs (aGPCRs), cannabinoid receptors (CB), and lysophosphatidic acid receptors (LPAR) in the field of kidney diseases. Hopefully, this review could enhance the understanding of GPCRs function and shed light on potential therapeutic targets for kidney disease treatment. |
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