宫内发育迟缓儿脐血胰岛素样生长因子-1、胰岛素和生长激素水平测定及意义

目的：研究宫内发育迟缓(IUGR)的发生与脐血中胰岛素样生长因子-1（IGF-1）、胰岛素（INS）和生长激素（GH）的关系，以探讨内分泌环境对胎儿IUGR的影响。方法：选择新生儿63例（男37例，女26例），根据出生体重分为IUGR组(n=33)和正常出生体重组(对照组，n=30)。测定并比较两组脐血中IGF-1、INS和GH的含量。结果：①IUGR组脐血中IGF-1和INS的水平均明显低于对照组, GH的水平明显高于对照组(P<0.05)。②相关分析显示出生体重与脐血中IGF-1水平呈正相关(r=0.625，P<0.01)，与GH水平呈负相关(r=-0.257,P<0.05)；胎龄与脐血中IGF-1水平呈正相关(r=0.271,P<0.05)。③多元线性逐步回归分析显示脐血IGF-1和INS水平是影响出生体重的重要因素。结论：内分泌环境调控胎儿的生长发育，脐血中的IGF-1和INS水平对胎儿体重有影响，IGF-1水平低下可能是导致IUGR 的原因之一。［中国当代儿科杂志，2010，12（10）：771-773］

Umbilical cord serum levels of insulin-like growth factor-1, insulin and growth hormone in neonates with intrauterine growth retardation

Objective To investigate the levels of insulin-like growth factor-1 (IGF-1) ,insulin ( INS) and growth hormone ( GH) in the cord blood of neonates with intrauterine growth retardation ( IUGR) ,and to assess the effects of the endocrine environment on IUGR. Methods Sixty-three newborn infants were selected,including 37 males and 26 females. According to birth weight,they were classified into IUGR group ( n = 33) and control group ( normal birth weight,n = 30) . The levels of IGF-1,INS and GH in the cord bloo...