慢性肺心病患者hs-CRP与NT-ProBNP的检测及临床意义

目的:探讨hs-CRP及NT-proBNP在慢性肺源性心脏病(PHD)中的变化及其意义。方法:将97例慢性阻塞性肺疾病(COPD)患者分为3组,检测单纯COPD组(A组28例)、COPD并发PHD代偿期组(B组36例)和COPD并发PHD失代偿期组(C组33例)hs-CRP及NT-proBNP值及COPD并发失代偿期PHD患者治疗后hs-CRP及NT–proBNP值。结果:3组患者hs-CRP及NT-proBNP值有极显著性差异(P<0.01),hs-CRP及NT-proBNP值为:C组>B组>A组。COPD并发失代偿期PHD患者治疗前与治疗后比较有极显著性差异(P<0.01)。结论:hs-CRP水平增高与PHD的发生、发展显著相关,对判断COPD患者病情及预后有指导意义。NT-proBNP浓度能较好反应COPD患者是否并发PHD及心功能状态。

Clinical significance of hs-CRP and NT-proBNP in patients with chronic pulmonary heart disease

Objective:To study the change and the significance of hs-CRP and NT-proBNP in the patients with chronic pulmonary heart disease(PHD).Methods: We recruited 97 patients in the same period after they received a diagnosis of COPD and divided them in to 3 groups.Group A contained 28 patients who had pure COPD.Group B contained 36 patients who had COPD,combined with chronic pulmonaryheart disease during compensatory stage.Group C contained 33 patients who had COPD combined with chronic pulmonary heart disease during decompensatory stage.We measured hs-CRP and NT-proBNP in plasma in these 97 patients and then analyzed the differences of its level among the 3 groups.Results: There were significant differences among hs-CRP and NT-proBNP levels in plasma of the 3 groups(P< 0.01).Each group of COPD patients hs-CRP,NT-proBNP serum level were: C group> B group> A group.After the therapy,the hs-CRP,NT-ProBNP serum levels significantly decreased with statistically differences(P<0.01).Conclusion: The increased hs-CRP levels are correlated with the occurring and developing of chronic pulmonary heart disease.The measurement of plasma NT-proBNP levels in patients with COPD can be used to identify whether they are combined with chronic pulmonary heart disease or heart insufficiency or not.