心衰及高血压患者检测血清NT-proBNP水平的临床意义

目的:探讨血清N末端脑钠肽(NT-proBNP)水平在高血压和心衰中的临床意义。方法:采用电化学发光免疫试验(ECLIA)进行血清NT-proBNP检测,统计学方法采用SPSS软件,两组间比较采用t检验,多组间比较采用单因素方差分析。结果:心衰组、高血压组血清NT-proB-NP水平与正常对照组之间均有显著差异,心衰组血清NT-proBNP 1864.03±3714.90(ng/L)、高血压组血清NT-proBNP 3061.87±7339.43(ng/L),均P<0.05;心衰组、高血压组男女血清NT-proBNP无显著性差异;心功能Ⅱ～Ⅳ级患者组各组间血清NT-proBNP均有显著性差异(F=83.95,P<0.05)。结论:血清NT-proBNP检测可用于评价患者的心功能状态,在临床诊断与疗效观察有非常重要的意义。

The clinical significance of detecting Cardiac failure and hypertension group in The Serum NT-proBNP

Objective:To explore NT-proBNP serum levels in the clinical significance of hypertension and heart failure.Methods:By using electrochemical luminescence immunoassay(ECLIA)to test the serum of NT-proB-NP;by SPSS statistical method,the two groups were compared by t test,while multiple groups were compared with one-way ANOVA.Results:Serum NT-ProBNP level between experimental groups(heart group、hypertension group)and control group were of significantly differenceheart group serum NT-proBNP1864.03±3714.90(ng/ L),hypertension group NT-proBNP serum 3061.87±7339.43(ng/L),P<0.05];in hf group and hypertension group,men and women’s NT-proBNP serum makes no significant difference;serum NT-proBNP of groups of pa-tients with CardiacⅡ～Ⅳlevel were significant difference(F=83.95,P<0.05).Conclusion:Serum NT-pro BNP testing can be used to evaluate the cardiac function of patients suffering from cardiovascular diseases,and it is of im-portant significance of clinical diagnosis and Therapeutic Observation.