存活素、血管内皮生长因子-C在结肠癌中的表达及其临床意义

目的探讨结肠癌组织中存活素（survivin）、血管内皮生长因子-C（VEGF-C）的表达,及其相互关系和临床意义。方法应用免疫组化法检测35例结肠癌组织和15例癌旁组织中survivin及VEGF-C的表达水平。结果结肠癌组织中survivin、VEGF-C阳性表达率分别为60.0%、65.7%显著高于癌旁非癌组织的13.3%（P〈0.05）。survivin、VEGF-C蛋白的表达与结肠癌的浸润深度、淋巴结转移及TNM分期有关（P〈0.05或P〈0.01）,与患者性别、年龄、结肠癌分化程度、远处转移无关（P〉0.05）。survivin、VEGF-C的表达呈正相关（P〈0.01）。结论结肠癌组织中survivin、VEGF-C表达均增高并且呈正相关。两者在结肠癌淋巴结转移中有协同效应,共同促进结肠癌的淋巴转移。

Expression and Clinical Significance of survivin, VEGF-C in Human Colon Cancer

Objective To investigate the relationship between the expression of survivin, VEGF-C and the clinicopathologic parameters in colon cancer. And evaluate the clinical significance. Methods 35 colon cancer tissues, 15 adjacent noncancerous specimens were obtained. Survivin, VEGF-C protein expression were evaluated by immunohistochemical analysis. Results Survivin and VEGF-C were overexpressed in colon camcer tissues （60. 0%, （65.7 % ） were significantly higher than those in noncancerous tissues （ 13.3 % ） （P 〈 0. 05 ）. Both survivin and VEGF-C expression correlated with depth of invasion,lymph node metastasis and TNM classification（P 〈0. 05 or P0. 01 ）. On the other hand,correlations were nil with regard to gender and age of the patients, histological type and distant metastasis （ P 〉 0.05 ）. There was positive correlation between the expression of survivin and VEGF-C （ P 〈 0. 01 ）. Conclusion Survivin overexpression was significantly associated with elevated VEGF-C. The co-expression of survivin and VEGF-C might play an important role in lymphatic spread of colon cancer.