睡眠剥夺对健康青年男性工作记忆的影响及莫达非尼的干预作用

目的 探讨不同时间睡眠剥夺对健康青年男性工作记忆的影响,以及莫达非尼对睡眠剥夺的对抗作用. 方法 10名健康男性青年志愿者进行间隔1周的3次36 h睡眠剥夺,第一次不服药,为剥夺组,后2次志愿者交叉服用莫达非尼和安慰剂(于睡眠剥夺14 h和24h 2次服用1.每次服药后3 h进行工作记忆任务测试(倒数n项测验),剥夺组也在同样的时间进行测试.把睡眠剥夺前清醒时设为正常对照组.并进行测试. 结果 剥夺组的1-back任务的第2次测试平均反应时间较第1次测试明显延长,2-back任务的第2次测试平均反应时间、错误率较第1次测试明显增高,差异均有统计学意义(P＜0.05).剥夺组的l-back任务的第2次测试错误率与平均反应时间均比正常对照组明显增高,2-back任务的两次测试平均反应时间和错误率较正常对照组明显增高,差异均有统计学意义(P＜0.05).莫达非尼组的1-back任务的第2次测试平均反应时间较剥夺组明显降低,2-back任务的两次测试平均反应时间和错误率较剥夺组明显降低,差异均有统计学意义(P＜0.05). 结论 睡眠剥夺后工作记忆受到损害,并随着剥夺时间延长,受损加重.莫达非尼对睡眠剥夺后的工作记忆损害有明显的改善作用.

Effects of modafinil on working memory after sleep deprivation in healthy volunteers

Objective To observe the changes in the working memory after sleep deprivation (SD)and the effect of modafinil in improving the working memory after SD in healthy volunteers.Methods Ten healthy young male volunteers were exposed to 36-h SD for 3 times at the interval of 1 week,with the waking state before SD as the normal control.In the first SD,the subjects were not given any medications to serve as the SD group,and in the latter two SDs,placebo(placebo group)or modafinil (modafinil group)were given at 14 and 24 h during the SD.The n-back task was performed to assess the working memory of the subjects 3 h after the medications or at the corresponding time point in the SD group.Results In the SD group,the working memory in the first test was better than that in the second test.The placebo and modafinil groups showed better performance in the test than the SD group.No significant differences were found in the performance in the first test between placebo group and modafinil group,but in the second test,the modafmil group showed better performance than the placebo group(P＜0.05).Conclusion Significant impairment of the working memory occurs after SD in healthy volunteers,and worsens as the SD prolongs.Modafinii can significantly improve the working memory after SD in healthy volunteers.