| rhTNF-NB与DDP联合应用治疗恶性胸腔积液38例 |
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| 引用本文： | 马耀先,刘润森,赵宏亮.rhTNF-NB与DDP联合应用治疗恶性胸腔积液38例[J].肿瘤基础与临床,2002,15(5):343-344. |
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| 作者姓名： | 马耀先 刘润森 赵宏亮 |
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| 作者单位： | 许昌市中心医院,河南,许昌,461000 |
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| 摘 要： | 目的 观察rhTNF -NB与DDP联合化疗药物 ,胸腔内灌注对恶性胸水的疗效。方法 采用胸腔穿刺灌注rhTNF -NB及DDP与单用DDP的疗效对照。结果 rhTNF -NB与DDP组 3 8例有效率 86 8% ;化疗组DDP 3 6例 ,有效率 47 2 % (P <0 0 5 )。结论 胸腔穿刺灌注rhTNF -NB及DDP组疗效明显优于胸腔内单纯灌注化疗药物DDP组 ,因此 ,rhTNF -NB及DDP胸腔内灌注为治疗恶性胸水的有效方法之一。
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| 关 键 词： | 生物治疗 联合化疗 新型重组人肿瘤坏死因子 恶性胸腔积液 |
| 文章编号： | 1003-1464(2002)04-0343-02 |
| 修稿时间： | 2001年12月24 |
rhTNF - NB and Cisplatin Combined Therapy in the Treatment of Malignant Pleural Effusion:A Report of 38 Cases |
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| MA Yao-xian,LIU Run-sen,ZHAO Hong-liang.rhTNF - NB and Cisplatin Combined Therapy in the Treatment of Malignant Pleural Effusion:A Report of 38 Cases[J].journal of basic and clinical oncology,2002,15(5):343-344. |
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| Authors: | MA Yao-xian LIU Run-sen ZHAO Hong-liang |
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| Abstract: | Objective To evaluate the result of combination therapy of rhTNF-NB and cisplatin in the treatment of malignant pleural effusion.Methods At first the pleural effusion was drained from an intrapleural catheter and then infused the rhTNF-NB plus cisplatin,and the control group was with infused cisplatin alone.Their therapeutic effects were compared in a randomized trial.Results The response rate of 38 cases of rhTNF-NB group was 86.8%,whereas that of the 36 cases of control group was 47.2% ( P <0.05).Conclusions The results showed that the effect of rhTNF-NB is superior to that of the cisplatin alone and it may be one of the effective ways to control malignant pleureal effusion. |
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| Keywords: | biological therapy combined-chemotherapy rhTNF-NB malignant pleural effusion |
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